Amphipathic Scaffold Composition for Dysbiosis Prevention

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Solution Overview

Problem

Current therapies for dysbiosis, including probiotics and antibiotics, have shown uncertain safety and effectiveness, highlighting the need for improved prevention and treatment methods that can effectively balance the microbiome and maintain a healthy ecosystem.

Innovation Solution

A composition comprising olive oil or olive fruit extract, betaine, and xylitol is used to create a three-dimensional amphipathic scaffold that enhances the resilience of the microbiome ecosystem, promoting a balanced microbiota and preventing the penetration of detrimental agents while maintaining hydration and nutrients.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If probiotics or antibiotics are used to treat dysbiosis, then the microbiome balance may be improved, but the safety and effectiveness remain uncertain

Engineering Contradiction:

Improvesafety and effectivenessVSAvoidmicrobiome balance

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The invention changes the fundamental parameters of treatment by shifting from microbial supplementation (probiotics) or eradication (antibiotics) to ecosystem enhancement through a 3D scaffold composed of specific ingredients (olive oil, betaine, xylitol) that restore physical and chemical conditions for microbial balance

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The composition acts as an intermediary substance that mediates between the host and the microbiome, providing a 3D scaffold that enhances resilience and balance without directly targeting specific microbes, thus avoiding the uncertainty of probiotic/antibiotic approaches

Inventive Principle:

Principle #24Intermediary (Mediator)

2Ease of manufacture

If conventional therapies are used, then treatment approach is simple, but the effectiveness is uncertain

Engineering Contradiction:

Improvetreatment simplicityVSAvoideffectiveness

Core Design Contradiction:

Ease of manufactureVSReliability

Solution Approach 1:

The invention uses a composite composition combining multiple ingredients (olive oil, betaine, xylitol) in specific proportions to create a 3D scaffold structure that provides synergistic effects, enhancing effectiveness while maintaining formulation simplicity

Inventive Principle:

Principle #40Composite materials

3Reliability

If the microbiome ecosystem is enhanced, then resilience and balance are improved, but the complexity of the system increases

Engineering Contradiction:

Improveecosystem resilienceVSAvoidsystem complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The invention segments the complex microbiome ecosystem into a simplified 3D scaffold structure composed of specific ingredients, allowing targeted enhancement of resilience without managing the full complexity of the entire microbial community

Inventive Principle:

Principle #1Segmentation

Data Source

PatentUS20230041103A1Composition for the prevention and treatment of dysbiosis

Publication Date: 2023.02.09 MUCOSA INNOVATIONS SL

AI summary

The present invention refers to a composition for use in the prevention and/or treatment of dysbiosis. It also refers to the use of said composition for preparing a medicament for the prevention and/or treatment of dysbiosis. Furthermore, it refers to a method of preventing and/or treating of dysbiosis in which said composition is administered to a subject in need thereof.