Amylopectin-Based Cyclic Glucan for Phytochemical Delivery
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Solution Overview
Problem
Current methods for modifying starch structures are limited by high environmental pollution and costs, and existing delivery systems for phytochemicals face issues with solubility and bioavailability, particularly for fat-soluble compounds.
Innovation Solution
A method for producing amylopectin-based cyclic glucan using a combination of starch degradation and trans-glycosidase-catalyzed reactions, followed by physical field-assisted solid dispersion to create phytochemical-amylopectin-based cyclic glucan inclusions, enhancing solubility and bioavailability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If chemical modification method is used to modify starch structure, then modification degree is improved, but modification cost increases and environmental pollution occurs
Solution Approach 1:
The patent changes the fundamental parameter of modification approach from chemical to physical/enzymatic methods. The physical modification method uses mechanical energy input (ultrasonic, micro-wave, high pressure) to alter starch structure without chemical reagents, while enzymatic modification uses biological catalysts under mild conditions, both achieving structural modification without the harmful effects of chemical methods.
Solution Approach 2:
The patent replaces chemical modification systems with physical field systems (ultrasonic, micro-wave, high pressure) and enzymatic systems. These physical and biological systems achieve starch structure modification through physical energy input and biological catalysis rather than chemical reactions, eliminating the need for harsh chemicals and their associated environmental problems.
2Stability of the object's composition
If cyclodextrin is used as wall material for microcapsules, then stability of core material is improved, but water solubility and bioavailability remain low
Solution Approach 1:
The patent creates a composite encapsulation system combining cyclodextrin with proteins and/or lipids to form complex wall materials. This composite structure leverages the cavity-forming ability of cyclodextrin for stability while incorporating protein or lipid components that enhance water solubility and bioavailability, overcoming the limitations of pure cyclodextrin microcapsules.
Solution Approach 2:
The patent applies different wall materials to different regions or aspects of the microcapsule system. Cyclodextrin provides the core cavity structure for stability, while protein or lipid components are incorporated to specifically address solubility and bioavailability requirements, creating localized functional zones within the encapsulation system.
3Ease of manufacture
If protein is used as emulsifier, then emulsion formation is achieved, but environmental sensitivity causes aggregation and precipitation at isoelectric point
Solution Approach 1:
The patent combines protein emulsifiers with other components (cyclodextrin, lipid, or small molecule compounds) to create composite emulsion systems. This composite approach maintains the emulsion formation capability of proteins while the additional components buffer against environmental sensitivity, preventing aggregation and precipitation at the isoelectric point through synergistic interactions.
4Reliability
If lipid carrier is used for active ingredient delivery, then targeted cell absorption is achieved, but structural damage occurs under pH or enzyme conditions
Solution Approach 1:
The patent employs a nested encapsulation structure where lipid carriers are protected within an outer matrix of protein, cyclodextrin, or other stabilizing materials. This nested design allows the lipid carrier to perform its targeted absorption function while the outer protective layer shields it from pH and enzymatic damage in the gastrointestinal tract, maintaining structural integrity until delivery.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method results in a high-yield, cost-effective, and environmentally friendly amylopectin-based cyclic glucan with improved solubility and bioavailability, suitable for various applications in food, medicine, and cosmetics, effectively addressing the limitations of existing starch modification and delivery systems.
Implementation Method 1
adding a trans-glycosidase preparation; the trans-glycosidase preparation can bind to and cut the α-1,4-glucosidic bond in the starch chain and cause a sugar chain to transfer to form a new cyclic chain structure
Implementation Method 2
adding an acid catalyst to carry out a degradation reaction of the starch
Implementation Method 3
a phytochemical-amylopectin-based cyclic glucan inclusion is prepared by a physical field-assisted solid dispersion technique, thereby improving nutritional quality of fat-soluble functional factors
Data Source
AI summary
The present disclosure discloses an amylopectin-based cyclic glucan and the processing method for the same, and belongs to the technical field of food processing. The present disclosure uses a starch as a raw material, prepares an amylopectin-based cyclic glucan through sugar chain degradation grading and glycosidase-catalyzed trans-glycoside technology, and can be used as a steady-state carrier material for food active factors. The method of the disclosure has advantages of green environmental protection, high processing yield and low cost. The prepared product has high branching degree, special large ring structure and good water solubility, and can be used for steady-state delivery and active protection of natural functional substances, involving nutritional food, medicine, daily chemicals and other fields.