Analgesic Composition with Caffeine and B Vitamins for Rapid Pain Relief

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Solution Overview

Problem

Current pain management strategies, particularly using non-steroidal anti-inflammatory drugs (NSAIDs), often result in delayed onset of pain relief and can cause significant side effects, including gastrointestinal issues and cardiovascular risks, especially in older adults or those with pre-existing conditions.

Innovation Solution

A pharmaceutical composition combining analgesics, caffeine, and B vitamins is administered to hasten and enhance the analgesic and anti-inflammatory response, reducing the need for higher doses of analgesics and minimizing side effects by shortening the onset time and extending the duration of pain relief.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If NSAIDs are used to treat pain and inflammation, then analgesic and anti-inflammatory effects are achieved, but the onset time is delayed and side effects occur

Engineering Contradiction:

Improveanalgesic effectivenessVSAvoidonset time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

Caffeine is included in the composition to perform preliminary action by accelerating gastric emptying and enhancing the absorption rate of the analgesic, thereby reducing the onset time before the main analgesic effect takes place

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent changes the pharmacokinetic parameters of the analgesic by combining it with caffeine and B vitamins, which modify the absorption, distribution, and metabolism rates to achieve faster onset and extended duration of action

Inventive Principle:

Principle #35Parameter changes

2Reliability

If higher doses of analgesics are administered to improve pain relief, then analgesic effectiveness is enhanced, but side effects increase

Engineering Contradiction:

Improveanalgesic effectivenessVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent extends the duration of analgesic action through combination with caffeine and B vitamins, allowing lower doses to achieve the same total analgesic effect over time, thereby reducing peak concentration-related side effects

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

B vitamins act as intermediaries that support metabolic processes and may reduce the formation of toxic metabolites from analgesic breakdown, thereby mitigating side effects while maintaining effectiveness

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If NSAIDs are used to relieve pain, then analgesic response is achieved, but gastrointestinal issues and cardiovascular risks occur

Engineering Contradiction:

Improvepain reliefVSAvoidgastrointestinal bleeding and cardiovascular events

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent reduces the required dose of NSAID by enhancing absorption with caffeine and extending duration with B vitamins, thereby lowering the overall burden on gastrointestinal and cardiovascular systems while maintaining pain relief effectiveness

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS9066950B2Analgesic compositions

Publication Date: 2015.06.30 GM PHARMA

AI summary

Embodiments of the invention relates to pharmaceutical compositions for use in the treatment of pain and inflammation in mammals, including humans, by administering compositions comprising i) an effective amount of an analgesic having an optional anti-inflammatory effect; (ii) an amount of caffeine effective in enhancement of pain relief; and, (iii) an amount of B vitamins effective in enhancement of pain relief.