High-Voltage Analog Pulser With Feedback for nsPEF Pulse Control
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Solution Overview
Problem
Current nanosecond pulsed electric field (nsPEF) technologies lack effective control over electrical characteristics, such as duration, amplitude, and temperature, which is crucial for safe and efficient cancer treatment, particularly for internal tumors.
Innovation Solution
A nanosecond pulsed electric field generator with a feedback control system that adjusts supply voltage, pulse width, frequency, and duty cycle based on measured parameters like current, voltage, and temperature to generate controllable high-voltage short-duration pulses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high-voltage pulses are generated for nsPEF treatment, then therapeutic effect on cancerous tumors is achieved, but control over electrical characteristics (duration, amplitude, temperature) is insufficient
Solution Approach 1:
The patent implements feedback control systems that continuously monitor electrical characteristics (voltage, current, temperature, pulse width) and adjust parameters in real-time to maintain precise control over the nsPEF pulses delivered to tissue, directly resolving the control insufficiency problem
Solution Approach 2:
The system employs dynamically adjustable parameters including pulse duration, amplitude, frequency, and duty cycle that can be modified during treatment based on tissue response and thermal conditions, enabling adaptive control without requiring complex system redesign
2Object-affected harmful factors
If nanosecond pulsed electric field is applied to induce apoptosis in cancerous tumors, then selective treatment of tumors is achieved, but impact on surrounding tissue must be minimized
Solution Approach 1:
The system delivers periodic nanosecond pulses with precisely controlled duration (0.1-1000 ns) and frequency (0.1-10,000 Hz), creating temporal patterns that selectively affect cancerous cells while allowing surrounding tissue to recover between pulses, thereby minimizing harmful effects on healthy tissue
Solution Approach 2:
The patent utilizes specific parameter ranges including high peak voltages (10-500 kV/cm), sub-microsecond pulse widths, and controlled duty cycles to create electrical fields that trigger apoptosis in cancer cells while maintaining safety margins for surrounding healthy tissue through precise parameter optimization
Data Source
AI summary
A sub-microsecond pulsed electric field generator is disclosed. The field generator includes a controller, which generates a power supply control signal and generates a pulse generator control signal, and a power supply, which receives the power supply control signal and generates one or more power voltages based on the received power supply control signal. The field generator also includes a pulse generator which receives the power voltages and the pulse generator control signal, and generates one or more pulses based on the power voltages and based on the pulse generator control signal. The controller receives feedback signals representing a value of a characteristic of or a result of the pulses and generates at least one of the power supply control signal and the pulse generator control signal based on the received feedback signals.