Sample Analysis Chip Delay Unit for Accurate Genetic Diagnosis
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Solution Overview
Problem
Conventional integrated genetic analysis devices face challenges such as high production costs, complexity, low reproducibility, and limitations in point-of-care testing due to complex chip structures and manual solution injection, which affect diagnostic accuracy and the ability to diagnose multiple viruses simultaneously.
Innovation Solution
A chip for sample analysis with a delay unit that allows the washing solution to reach the capture path later than the sample, combined with a cartridge for automatic solution injection, enabling improved diagnostic accuracy and the ability to diagnose multiple pathogens in one device.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If the washing solution is introduced before the sample is captured in the capture path, then the device can operate continuously, but the accuracy of the analysis is reduced
Solution Approach 1:
The delay unit is pre-configured with a specific volume capacity that automatically delays the washing solution by a predetermined time period, ensuring that the washing solution only reaches the capture path after the sample has been fully captured, thus maintaining analysis accuracy while enabling continuous operation
2Device complexity
If manual injection of solutions into each storage unit is performed, then the device structure can be simplified, but the time required for analysis increases and contamination risk increases
Solution Approach 1:
The cartridge is designed with self-aligning features including positioning protrusions that automatically fit into corresponding grooves on the chip, enabling the cartridge to self-position and self-seal with the chip without requiring manual alignment or complex positioning mechanisms, thus reducing manual handling time and contamination risk while maintaining structural simplicity
3Ease of operation
If a conventional rotary genetic diagnosis device is used, then one virus can be analyzed in one unit process, but numerous diseases cannot be diagnosed in one device
Solution Approach 1:
The chip is designed with multiple independent capture paths (first capture path, second capture path, etc.) that can simultaneously process different samples or target different viruses, making the device capable of diagnosing multiple diseases concurrently while maintaining the operational simplicity of single-virus analysis protocols
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution improves diagnostic accuracy by ensuring the washing solution is introduced after the sample is captured, allows for simultaneous diagnosis of multiple viruses, and reduces manual handling time, enhancing the ease and speed of genetic diagnosis.
Implementation Method 1
a delay unit included between the capture path and the washing solution storage unit such that a washing solution flowing from the washing solution storage unit to the capture path passes through. The delay unit is configured to delay the passage of the washing solution introduced from the washing solution storage unit such that the washing solution reaches the capture path later than the sample, when the chip is rotated for sample analysis
Data Source
AI summary
A chip for sample analysis is provided. The chip for sample analysis according to an embodiment of the present application includes a sample storage unit, a capture path configured to capture an analyte contained in a sample and communicating with the sample storage unit, a washing solution storage unit communicating with the capture path and a delay unit included between the capture path and the washing solution storage unit such that a washing solution flowing from the washing solution storage unit to the capture path passes through. When the chip is rotated for sample analysis, the delay unit may be configured to delay the passage of the washing solution introduced from the washing solution storage unit such that the washing solution reaches the capture path later than the sample.