Analysis Chip Dual-Region Noise Correction
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Solution Overview
Problem
Existing analysis devices using analysis chips for point-of-care testing face challenges in accurately measuring the concentration of substances due to noise signals from non-reacting substances in the sample, leading to reduced accuracy.
Innovation Solution
The use of an analysis device with two regions on a single or multiple analysis chips, where one region contains a reagent reacting with the substance to be tested and the other does not, allowing for the acquisition of separate detection signals to correct for noise and improve measurement accuracy by subtracting or dividing the signals to derive the concentration of the target substance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If only the detection signal from the reaction layer is acquired, then the measurement process is simple, but the measurement accuracy is reduced due to noise from non-reacting substances
Solution Approach 1:
The analysis chip is divided into two distinct regions: a first region containing the reaction layer with reagent, and a second region without reagent. This segmentation allows separate detection of reacting and non-reacting substances, enabling noise removal while maintaining operational simplicity.
Solution Approach 2:
The second region acts as an intermediary control that measures the baseline signal from non-reacting substances. This intermediary measurement is then used to correct the detection signal from the first region, improving accuracy without complicating the overall process.
2Device complexity
If a single analysis chip with two regions is used, then device complexity is reduced, but signal separation becomes more difficult
Solution Approach 1:
Different regions of the analysis chip are given different local qualities: the first region contains reagent for reacting with target substances, while the second region lacks reagent to capture only baseline signals. This local differentiation enables automatic signal separation through spatial distribution.
Solution Approach 2:
The problem of signal separation is solved by adding a spatial dimension - distributing different functional regions (with and without reagent) across different areas of the chip. This transforms a complex signal processing problem into a simpler spatial measurement problem.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables more accurate measurement of the substance's concentration by isolating the signal from the reactant, thereby reducing interference from other substances, enhancing the overall precision of the analysis.
Implementation Method 1
a light source that irradiates the analysis chip with light; a photodetector that detects output light, which is output from the analysis chip in a case in which the analysis chip is irradiated with the light
Implementation Method 2
the substance to be tested in the sample reacts with the reagent in the reaction layer to generate a reactant that develops a color
Data Source
AI summary
An analysis device uses a single or a plurality of analysis chips having two regions of a first region, which has a reagent reacting with a substance to be tested, and a second region, which does not have the reagent. The analysis device includes a light source that irradiates the analysis chip with light, a photodetector that detects output light, which is output from the analysis chip, and that outputs a first detection signal corresponding to the output light from the first region and a second detection signal corresponding to the output light from the second region, and a processor that acquires the first detection signal and the second detection signal from the photodetector and that corrects the first detection signal with the second detection signal to derive a concentration of the substance to be tested included in the sample.