Analysis Chip Water Repellent Connection Portion Background Noise
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Solution Overview
Problem
Analysis chips face challenges in reducing background noise due to unreacted labeled substances adhering to water repellent surfaces, which affects data accuracy during the washing process.
Innovation Solution
The analysis chip design incorporates a water repellent treatment on the substrate's surface, forming a connection portion that extends from the partition portion to the corner, creating a continuous water repellent surface to prevent unreacted labeled substances from adhering and facilitating efficient washing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If water repellent material is used to partition reaction portions, then sample contamination between adjacent reaction portions is prevented, but unreacted labeled substance adheres to the water repellent surface causing background noise
Solution Approach 1:
The water repellent surface is segmented into two distinct regions: a partition portion that surrounds each reaction portion to prevent sample contamination, and a connection portion that extends to the substrate edge to enable washing liquid flow. This segmentation allows each region to fulfill its specific function without interfering with the other.
Solution Approach 2:
Different regions of the water repellent surface are given different functional qualities: the partition portion has strong water repellency for contamination prevention, while the connection portion has extended reach to the substrate edge for washing facilitation. This local differentiation resolves the contradiction between contamination prevention and background noise reduction.
2Object-affected harmful factors
If water repellent surface is extended to prevent contamination, then sample spillage is contained, but washing liquid cannot efficiently remove unreacted labeled substance
Solution Approach 1:
The water repellent surface is divided into a partition portion for spill containment and a connection portion for washing liquid access. The connection portion extends to the substrate edge, creating a pathway for washing liquid to reach and remove unreacted labeled substance from the water repellent surface.
Solution Approach 2:
The connection portion acts as an intermediary between the partitioned reaction portions and the external washing liquid source. It provides a designated pathway that allows washing liquid to access the water repellent surface without compromising the spill containment function of the partition portion.
3Stability of the object's composition
If sheet-like separator is used for partitioning, then chemical uniformity of substrate surface is maintained, but detachment and storage become difficult
Solution Approach 1:
The partition portion and connection portion are merged into a single integrated water repellent surface structure. This eliminates the need for separate sheet-like separators, maintaining chemical uniformity while providing a fixed structure that is easier to store and handle.
Solution Approach 2:
The water repellent surface serves multiple functions simultaneously: it maintains chemical uniformity of the substrate surface, partitions reaction portions to prevent contamination, and provides a fixed structure that is easier to store and handle compared to detachable separators.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This design effectively reduces background noise by ensuring unreacted labeled substances are washed off, leading to more accurate substance detection and quantification.
Implementation Method 1
water repellent treatment on the substrate surface, forming a connection portion that extends from the partition portion to the corner, creating a continuous water repellent surface
Implementation Method 2
ensuring unreacted labeled substances are washed off, leading to more accurate substance detection and quantification
Data Source
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AI summary
An analysis chip according to the present invention includes a substrate main body having a plurality of reaction portions in which a selective binding substance selectively binding to a substance to be examined is immobilized; a corner portion in which different straight lines or curved lines intersect with each other in a cross section in which a plane passing through a surface of the substrate main body on which the reaction portions are provided is a cut surface; a partition portion formed by applying water repellent treatment to the surface of the substrate main body on which the reaction portions are provided and partitioning the reaction portions inside an outer edge formed by the surface, and a connection portion having water repellency and connecting between a part of the partition portion and the corner portion.