Automatic Analysis Device Pressure Waveform Area Detection
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Solution Overview
Problem
Existing automatic analysis devices struggle to detect dispensing abnormalities, such as bubble suction, with high sensitivity, especially when the sample dispensing amount is small and there is no significant difference in pressure waveform between normal and abnormal cases.
Innovation Solution
The device includes a probe, syringe, and pressure sensor to measure pressure changes during dispensing, with a storage unit for a reference discharge pressure waveform and a determination unit that assesses the difference or ratio between this reference and the actual pressure waveform to detect abnormalities, enhancing sensitivity and accuracy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If pressure integrated value or pressure change rate is used to detect dispensing abnormalities, then abnormalities with large pressure waveform differences can be detected, but abnormalities cannot be detected when the sample dispensing amount is small and no significant difference in pressure waveform is found
Solution Approach 1:
The invention changes the detection parameter from pressure integrated value or pressure change rate to the area of the pressure waveform. This parameter change enables detection of abnormalities even when the sample dispensing amount is small and no significant difference in pressure waveform is found, as the area measurement provides a more sensitive indicator for detecting subtle abnormalities in the pressure waveform.
2Measurement precision
If conventional pressure waveform analysis methods are used, then the device complexity remains low, but the measurement precision for detecting small abnormalities is insufficient
Solution Approach 1:
The invention replaces complex mechanical or multi-parameter analysis systems with a simplified area-based detection method. Instead of analyzing multiple pressure waveform characteristics (integrated value, change rate, etc.), the system simply calculates the area of the pressure waveform, achieving high detection precision with minimal device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution allows for accurate detection of bubble suction and other abnormalities regardless of the dispensing amount, improving the reliability of automatic analysis devices by distinguishing between normal and abnormal waveforms even when differences are subtle.
Implementation Method 1
a pressure sensor that measures the pressure change in the flow path at the time of liquid dispensing
Data Source
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Figure 3(a)~3(b)
AI summary
An object of the present invention is to provide an automatic analysis device which can detect a dispensing abnormality at a high sensitivity regardless of the degree of the abnormality even in a case where the dispensing amount of liquid is small. An automatic analysis device includes a probe that performs a dispensing operation including a suction process and a discharge process with respect to liquid; a syringe that generates a pressure change for dispensing liquid at the probe; a flow path that connects the probe and the syringe with each other; a pressure sensor that measures the pressure change in the flow path at the time of liquid dispensing; a storage portion that stores a pressure change of time-series when reference fluid is discharged as a reference discharge pressure waveform; and a determination portion that determines whether or not there is an abnormality in the suction process of the sample from a relationship between a value of difference or a ratio between the reference discharge pressure waveform and the pressure waveform of a determination target at the time of discharge of liquid and normal range.