Analyte Quantification With Background Drift Correction
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Solution Overview
Problem
Existing methods fail to accurately quantify analytes in measurement systems where the analyte amount increases or decreases during measurement due to adsorption on the inner walls of measurement apparatuses, leading to incorrect quantification results.
Innovation Solution
A quantifying method involving multiple measurements of the same sample using one or multiple measurement apparatuses to calculate and correct for the change in analyte amount, allowing for accurate quantification by determining the true quantitative value.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If water adsorbed on the inner wall of the measurement apparatus is removed by heating, then the background is reduced, but mechanical changes occur in the measurement system affecting quantification accuracy
Solution Approach 1:
The patent applies preliminary action by performing multiple measurements before the actual sample analysis to determine the background amount of analyte generated by water adsorption. This preliminary characterization allows the system to account for and correct the background interference without requiring extreme measures like high-temperature heating that would cause mechanical changes.
2Measurement precision
If multiple measurements are performed to determine background amount, then quantification accuracy is improved, but measurement time increases
Solution Approach 1:
The patent applies partial action by performing a limited number of preliminary measurements (excessive enough to statistically determine background, but not excessive to waste time) to characterize the background amount. This optimized approach balances the need for accurate background determination with the constraint of measurement time, avoiding both insufficient sampling and excessive redundancy.
3Ease of operation
If the analyte and background are present in the same space, then the measurement is simpler, but reducing background signal also reduces analyte signal
Solution Approach 1:
The patent applies the extraction principle by mathematically separating the background signal from the total measured signal. By determining the background amount through preliminary measurements and subtracting it from the total signal, the method effectively extracts and removes the background contribution, allowing accurate quantification of the analyte even though both are present in the same physical space.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate quantification of analytes by correcting for changes caused by adsorption on measurement apparatuses, improving measurement precision.
Implementation Method 1
water adsorbed on the inner wall of piping or a vessel
Implementation Method 2
the substance is hydrolyzed upon contact with water adsorbed on the inner wall
Data Source
AI summary
The present invention is a quantifying method by which a sample containing an analyte is quantified for the analyte, the method including steps of: (1) measuring the same sample a plurality of times by using a measurement apparatus to obtain a plurality of quantitative values of the analyte in the sample; and (2) calculating an amount of change in the analyte derived from the measurement apparatus from the plurality of the quantitative values, and correcting at least one of the plurality of the quantitative values with the amount of change to obtain a true quantitative value of the analyte. This provides a method for more accurately quantifying an analyte in a measurement system in which an amount of the analyte increases or decreases in a measurement apparatus during measurement of the sample.