Analyte Sensor Calibration Frequency Based on Indicator Degradation
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Solution Overview
Problem
Current blood glucose monitoring methods, such as finger-stick tests, are burdensome and provide limited information about intraday fluctuations, leading to poor glycemic control in diabetes management, while continuous glucose monitors (CGMs) can improve this but require frequent calibration, which is inconvenient for patients.
Innovation Solution
A dynamic calibration frequency system for analyte sensors that adjusts based on the degradation rate of the analyte indicator, increasing frequency when degradation is high and decreasing it when low, using sensitivity and degradation rate calculations to optimize calibration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If frequent calibration is performed to maintain measurement accuracy, then measurement precision is improved, but ease of operation deteriorates due to increased user burden
Solution Approach 1:
The calibration frequency is made dynamic rather than fixed. The system continuously monitors the degradation rate of the analyte indicator and automatically adjusts the calibration frequency accordingly - increasing it when degradation is high and decreasing it when degradation is low, thereby optimizing the balance between measurement accuracy and user convenience
Solution Approach 2:
The system implements a feedback loop where the degradation rate of the analyte indicator is continuously measured and used to adjust the calibration frequency. This closed-loop control ensures that calibration occurs only when necessary, maintaining accuracy while reducing unnecessary user interventions
2Device complexity
If fixed calibration frequency is used, then device complexity is reduced, but adaptability deteriorates because it cannot respond to changing sensor degradation rates
Solution Approach 1:
The system transitions from a static fixed calibration schedule to a dynamic adaptive calibration frequency that automatically responds to real-time sensor conditions, allowing the calibration interval to extend or contract based on actual analyte indicator degradation rates
Solution Approach 2:
The calibration frequency parameter is changed from a fixed value to a variable that depends on the degradation rate parameter. The system calculates the degradation rate and uses it to determine the appropriate calibration frequency, thereby adapting to changing sensor performance characteristics
Data Source
AI summary
Methods, systems, and apparatuses for dynamic modification of calibration frequency. Dynamic modification of calibration frequency may include one or more of: receiving sensor data conveyed by an analyte sensor comprising an analyte indicator, using the sensor data to calculate one or more analyte levels, and receiving one or more reference analyte level measurements. Dynamic modification of calibration frequency may include using the sensor data, the one or more calculated analyte levels, and/or the one or more reference analyte level measurements to calculate a degradation rate of the analyte indicator of the analyte sensor. Dynamic modification of calibration frequency may include setting a dynamic calibration frequency based on the calculated degradation rate.