Analyte Concentration Correction via Adjustment Information
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Solution Overview
Problem
Existing analytical methods, such as Gas Chromatograph (GC) and Gas Chromatograph-Mass Spectrometer (GC-MS), face challenges in accurately analyzing the concentration or mass of an analyte due to influencing substances in the sample, leading to increased analysis costs and complexity.
Innovation Solution
An analysis method and device that derive the concentration of an analyte by using adjustment information based on sample analysis data, generated from standard and reference samples, to correct for the influence of secondary substances, allowing for accurate and efficient analysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a plurality of reference samples containing the same substance as that of a sample to be analyzed but containing a component to be analyzed at different concentrations are prepared to obtain a calibration curve, then the concentration or mass of the analyte can be analyzed more accurately, but the procedure becomes complicated and time-consuming, leading to increased analysis cost
Solution Approach 1:
The patent applies preliminary action by pre-calculating correction values based on the known influence relationships between influencing substances and analytes. Instead of performing complex multi-concentration reference sample analysis for each sample, the system pre-establishes correction factors that can be directly applied during routine analysis, significantly simplifying the procedure while maintaining accuracy
Solution Approach 2:
The patent changes the parameter approach from using multiple reference samples with different analyte concentrations to using correction values derived from the relationship between influencing substance content and signal intensity. This parameter transformation simplifies the analysis procedure while preserving measurement accuracy
2Measurement precision
If a plurality of reference samples containing the same substance as that of a sample to be analyzed but containing a component to be analyzed at different concentrations are prepared to obtain a calibration curve, then the concentration or mass of the analyte can be analyzed more accurately, but it takes time and effort, leading to increased analysis cost
Solution Approach 1:
The system performs preliminary calculations to establish correction values based on the influence relationships before actual sample analysis. This allows routine analyses to proceed quickly by simply applying pre-determined correction factors rather than performing time-consuming reference sample measurements for each sample
Solution Approach 2:
The patent creates a simplified computational model that copies the essential correction functionality from complex reference sample analysis. Instead of physically preparing and analyzing multiple reference samples, the system uses calculated correction values that replicate the accuracy benefits without the time cost
3Productivity
If adjustment information is used to correct for the influence of influencing substances, then the analysis can be performed more efficiently with reduced time and cost, but the method requires establishing correction values based on known influence relationships
Solution Approach 1:
The patent transforms the analysis approach by changing from direct measurement correction to parameter-based correction. Correction values are calculated based on the relationship between influencing substance content and signal intensity, allowing efficient application through simple parameter multiplication or addition rather than complex procedural adjustments
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate and efficient analysis of analyte concentration in samples containing influencing substances, reducing analysis time and cost by using adjustment calibration curves to correct for interference.
Implementation Method 1
a detection signal intensity related to the concentration or mass of an analyte
Implementation Method 2
Gas Chromatograph-Mass Spectrometer (GC-MS)
Implementation Method 3
Gas Chromatograph (GC)
Implementation Method 4
pyrolysis gas chromatography-mass spectrometry (Py-GC/MS)
Data Source
AI summary
An analysis method of performing an analysis on a sample containing a first substance and a second substance that has an influence on an analysis of the first substance in regard to a concentration of the first substance, includes performing an analysis on the sample in regard to the concentration of the first substance to obtain sample analysis data, and deriving a result of analysis in regard to a concentration of the first substance based on the sample analysis data and adjustment information that is set based on the influence.