Analyte Detection Device Using Magnetic Particle Transport
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Solution Overview
Problem
Conventional immunoassay devices are complex and large due to the need for pumps, washing buffers, and transfer units, making them inefficient for automated analyte detection.
Innovation Solution
An analyte detection device with a sample chamber, a detection chamber, and a channel in between, using moving means such as gravity, centrifugal force, or magnetic force to move particles from the sample chamber to the detection chamber without mixing with the detection solution, eliminating the need for liquid transfer units.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Extent of automation
If conventional immunoassay devices use pumps, washing buffers, and transfer units for automated analyte detection, then automation and detection capability are improved, but device complexity and size increase
Solution Approach 1:
The patent extracts and eliminates the need for complex liquid transfer units, pumps, and washing buffer systems by redesigning the device to use magnetic particle-based separation and detection. The invention removes unnecessary components while retaining automated detection capability through a simplified architecture that uses magnetic fields instead of mechanical liquid handling.
Solution Approach 2:
The patent makes the magnetic particles serve multiple functions: they act as both the capture reagent载体 and the detection target, eliminating the need for separate transfer units. The magnetic field application unit serves both to move particles during separation and to concentrate them during detection, reducing the need for multiple specialized components.
2Extent of automation
If conventional immunoassay devices use pumps, washing buffers, and transfer units, then automated detection is achieved, but device size increases
Solution Approach 1:
The patent removes bulky liquid transfer units, pump systems, and washing buffer reservoirs from the device architecture. By using magnetic particle separation that requires only magnetic field application rather than mechanical liquid handling, the device volume is dramatically reduced while maintaining automated detection functionality.
3Reliability
If magnetic particles are used to capture analyte from sample, then pretreatment and separation are improved, but particle movement control complexity increases
Solution Approach 1:
The patent replaces complex mechanical particle manipulation systems with magnetic field-based control. Instead of using mechanical actuators to move and position particles, the invention uses magnetic field application units that can remotely manipulate magnetic particles through the sample, simplifying the control mechanism while improving particle capture reliability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device simplifies analyte detection by eliminating the need for liquid transfer units, reducing complexity and size, and enhancing economic efficiency by using gravity, centrifugal force, or magnetic force to move particles, thereby facilitating easier and more economical detection processes.
Implementation Method 1
moving means for moving the particles from the sample chamber to the detection chamber
Implementation Method 2
using moving means such as gravity, centrifugal force, or magnetic force to move particles
Implementation Method 3
using moving means such as gravity, centrifugal force, or magnetic force to move particles
Data Source
AI summary
The present invention relates to an analyte detection device comprising: a sample chamber for storing a mixture solution of a sample comprising an analyte and a reactant comprising particles; a detection chamber for storing a detection solution; and a channel placed between the sample chamber and the detection chamber to prevent the mixture solution and the detection solution from being mixed with each other, the analyte detection device characterized by detecting the analyte by moving the particles from the sample chamber to the detection chamber using moving means.