Analyte-Guided Dosage Calculation During Device Initialization
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Solution Overview
Problem
Automated drug delivery systems face inefficiencies when they lack sufficient patient analyte values, relying on conservative or default dosages, which do not account for the patient's current physiological condition, reducing their efficacy.
Innovation Solution
A drug delivery device and method that utilize present analyte measurements and stored backfill values to calculate and deliver drug dosages, ensuring accurate and safe administration even in the absence of real-time analyte measurements.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the automated drug delivery system uses conservative or default dosages during initialization, then safety is maintained, but treatment efficacy is reduced
Solution Approach 1:
The system performs preliminary actions by collecting and storing analyte values in a buffer memory during the warm-up period before initialization. These pre-collected values are then utilized immediately upon initialization to calculate accurate dosages, eliminating the need to rely on conservative default values and thereby improving treatment efficacy while maintaining safety.
2Measurement precision
If the system waits for sufficient analyte values during initialization, then accurate dosage calculation is achieved, but treatment delay occurs
Solution Approach 1:
The system performs preliminary data collection by accumulating analyte values in a buffer memory during the warm-up period. This pre-collected data is immediately available upon initialization, allowing the system to calculate accurate dosages without waiting for a minimum number of values to be collected during operation, thereby eliminating treatment delays while maintaining dosage accuracy.
3Speed
If the system uses default dosage during warm-up period, then immediate drug delivery is possible, but patient-specific treatment is not provided
Solution Approach 1:
The system performs preliminary data accumulation by collecting analyte values in a buffer memory during the warm-up period. These pre-collected patient-specific values are then used immediately upon initialization to calculate personalized dosages, enabling the system to provide both immediate drug delivery and patient-specific treatment without compromise.
Data Source
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AI summary
Disclosed are processes and techniques implementable by a drug delivery system to maintain optimal drug delivery for a patient according to a treatment plan. The disclosed techniques enable a new drug delivery device that is exchanged for a previous drug delivery device to operate using analyte-based drug delivery control immediately during initialization instead of having to wait for a warm-up period. For example, a drug delivery device may include a processor and a memory storing instructions that, when executed by the processor, operate the drug delivery device to receive a present analyte measurement value from an analyte sensor during an initialization of the drug delivery device, receive backfill values measured by the analyte sensor prior to the initialization, calculate a dosage of a drug using the present analyte measurement value and the backfill values, and deliver the dosage of the drug. Other embodiments are described.