Non-Invasive Analyte Imaging Using Reflection and Fluorescence Spectra
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Solution Overview
Problem
Existing analyte testing technologies face challenges such as invasiveness, high cost, complexity, and difficulty in achieving real-time, portable, and accurate non-invasive measurements due to issues like mixed spectral signals and interference from skin components.
Innovation Solution
A method and system utilizing broad-spectrum visible light, near-infrared light, and ultraviolet light to image and obtain reflection and fluorescence spectral data, enabling accurate selection of testing and reference points, and using a trained analyte testing model to analyze these data for non-invasive analyte concentration measurement.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If Raman spectroscopy is used for non-invasive analyte measurement, then measurement accuracy is improved, but device complexity and cost increase significantly
Solution Approach 1:
The patent extracts and eliminates the harmful spectral interference from skin components by separately measuring and subtracting the skin spectrum from the total spectrum. This allows use of simpler absorption spectroscopy while achieving accuracy comparable to complex Raman systems.
Solution Approach 2:
The patent changes the spectral measurement approach from Raman scattering to absorption spectroscopy, and introduces a dual-wavelength measurement method (with and without blood vessel areas) to extract analyte-specific spectral information while eliminating skin interference.
2Device complexity
If absorption spectroscopy is used for non-invasive testing, then device portability is improved, but measurement accuracy deteriorates due to mixed spectral signals
Solution Approach 1:
The patent segments the measurement area into two distinct regions: areas with blood vessels and areas without blood vessels. By separately measuring these regions and comparing the spectral differences, the analyte concentration can be determined while eliminating skin component interference.
Solution Approach 2:
The patent uses the skin area without blood vessels as an intermediary reference to subtract the skin's spectral contribution from the total spectrum. This reference measurement acts as a mediator to isolate the analyte-specific spectral signal.
3Measurement precision
If multiple biological signals are collected from different body positions, then measurement accuracy is improved, but device complexity and cost increase
Solution Approach 1:
The patent applies local quality by focusing measurement on specific local areas of the skin with distinct vascular characteristics. By selecting and comparing adjacent regions with and without blood vessels, the system achieves accurate measurement without needing multiple distributed sensors across different body parts.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate, non-invasive, and cost-effective real-time testing by distinguishing between areas with and without blood vessels, minimizing interference from non-analyte components, and achieving high measurement accuracy.
Implementation Method 1
irradiating the first area by ultraviolet light within a second wavelength range and imaging the first area, to obtain a second image of the imaging area; obtaining, from the first image, color or grayscale distribution data; based on the color or grayscale distribution data, obtaining, from the first image, reflection spectral data; and based on the color or grayscale distribution data, obtaining, from the second image, fluorescence spectral data
Data Source
AI summary
The present invention provides a method and a system for testing an analyte, a medium, and a device. The method includes: irradiating a first area by broad-spectrum visible light, infrared light, or visible-near-infrared light, and imaging the first area, to obtain an image of an imaging area; irradiating the first area by ultraviolet light within a second wavelength range, and imaging the first area, to obtain a second image of the imaging area; obtaining, from the first image, color or grayscale distribution data that indicate the analyte; based on the color or grayscale distribution data, respectively obtaining, from the first image and the second image, reflection spectral data and fluorescence spectral data at desired positions that indicate the analyte; and obtaining information about the analyte in the imaging area based on the reflection spectral data and fluorescence spectral data.