Analyte Measurement Interference Criticality Detection

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Solution Overview

Problem

Existing methods for determining analyte concentration in liquid samples are prone to errors due to interferents like cell-free hemoglobin, leading to erroneous results and the need for resource-intensive retesting.

Innovation Solution

An apparatus and method that measure both analyte concentration and cell-free hemoglobin concentration, using a data processing device to determine cell-free hemoglobin interference criticality based on both parameters, thereby mitigating measurement errors and reducing the need for retesting.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If only analyte concentration is measured, then measurement process is simple, but measurement accuracy deteriorates due to interferents like cell-free hemoglobin

Engineering Contradiction:

Improveanalyte concentration measurement accuracyVSAvoidmeasurement process complexity

Core Design Contradiction:

Measurement precisionVSDevice complexity

Solution Approach 1:

The patent introduces cell-free hemoglobin concentration measurement as an intermediary parameter to detect and quantify the interferent. By measuring this intermediate substance, the system can identify the presence and magnitude of interference, then apply compensation algorithms to correct the analyte concentration measurement, thereby resolving the contradiction between measurement simplicity and accuracy.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The system implements feedback by using the measured cell-free hemoglobin concentration to adjust and compensate the analyte concentration measurement. The interference criticality determination provides feedback information that enables real-time correction of measurement errors, improving accuracy without requiring complete redesign of the measurement process.

Inventive Principle:

Principle #23Feedback

2Measurement precision

If interferent compensation is implemented, then measurement accuracy improves, but device complexity increases due to additional sensors and processing

Engineering Contradiction:

Improveanalyte concentration measurement accuracyVSAvoidapparatus structure complexity

Core Design Contradiction:

Measurement precisionVSDevice complexity

Solution Approach 1:

The patent makes the measurement apparatus multi-functional by enabling it to measure both analyte concentration and cell-free hemoglobin concentration using the same sensor system. This universal approach allows a single device to perform both routine analyte measurement and interferent detection, avoiding the need for separate specialized devices and reducing overall system complexity.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The system changes measurement parameters by introducing cell-free hemoglobin concentration as an additional measured parameter. This parameter change enables the system to characterize the interference state and apply appropriate compensation, improving accuracy while managing complexity through systematic parameter expansion rather than structural overhaul.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If cell-free hemoglobin concentration is measured and interference criticality is determined, then erroneous measurements are reduced, but measurement time increases

Engineering Contradiction:

Improvemeasurement result reliabilityVSAvoidmeasurement process time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The system performs preliminary action by measuring cell-free hemoglobin concentration simultaneously with or before the analyte concentration measurement. This preliminary detection of interference allows the system to prepare compensation factors in advance, ensuring reliable corrected results without requiring additional sequential measurement steps that would extend total measurement time.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent maintains continuity of useful action by implementing parallel measurement of analyte concentration and cell-free hemoglobin concentration. Both measurements occur concurrently rather than sequentially, ensuring that the interference assessment does not interrupt or delay the primary analyte measurement, thus maintaining measurement efficiency while improving reliability.

Inventive Principle:

Principle #20Continuity of useful action

Data Source

PatentUS20240044918A1Determining interference criticality based on analyte and cell-free hemoglobin concentrations

Publication Date: 2024.02.08 RADIOMETER AS

AI summary

There is presented an apparatus (100) for automatically measuring an analyte concentration in a liquid sample (102) comprising the analyte and cell-free hemoglobin and for automatically determining a cell-free hemoglobin interference criticality, said apparatus comprising one or more sensors (104) for measuring the analyte concentration in the liquid sample, and a cell-free hemoglobin concentration in the liquid sample, and further comprising a data processing device (106) comprising a processor configured to determine the cell-free hemoglobin interference criticality based on the cell-free hemoglobin concentration, and the analyte concentration, and output a signal (108) indicative of the cell-free hemoglobin interference criticality at least in case the cell-free hemoglobin interference criticality is within a predetermined range.