Analyte Sensor with Antiglycolytic Agent for Immediate Glucose Accuracy

Solution Overview

Problem

Conventional glucose monitoring techniques for diabetics are invasive, inconvenient, and prone to spurious low readings, especially during the initial hours after sensor placement, which can lead to delayed or inaccurate glucose level reporting and increased risk of hyperglycemic or hypoglycemic episodes.

Innovation Solution

The development of analyte sensors with an antiglycolytic agent or its precursor, which are positioned beneath the skin to minimize spurious low readings by retarding glucose consumption by living cells, allowing for immediate and accurate glucose monitoring with reduced calibration requirements.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional analyte sensors are used, then continuous monitoring is achieved, but spurious low readings occur during the initial hours after positioning

Engineering Contradiction:

Improveaccuracy of analyte readingsVSAvoidtime delay before accurate readings are obtained

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The sensor is pre-calibrated in the laboratory before implantation, establishing an initial calibration curve that anticipates the sensor's response characteristics. This preliminary calibration action eliminates the need for post-implantation waiting periods and ensures immediate accurate readings by pre-compensating for any initial response delays.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The system incorporates feedback mechanisms that continuously monitor sensor responses and compare them against expected values. When deviations indicating spurious readings are detected, the system automatically adjusts or flags the measurements, ensuring only accurate analyte concentrations are reported to the user.

Inventive Principle:

Principle #23Feedback

2Reliability

If frequent calibration is performed to eliminate spurious readings, then reading accuracy improves, but device complexity and user convenience deteriorate

Engineering Contradiction:

Improveaccuracy of analyte readingsVSAvoidcalibration requirements

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The sensor is pre-calibrated in the laboratory before implantation, establishing an initial calibration curve that anticipates the sensor's response characteristics. This preliminary calibration action eliminates the need for post-implantation waiting periods and ensures immediate accurate readings by pre-compensating for any initial response delays.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The sensor system performs self-calibration using its inherent response characteristics and built-in reference mechanisms. The sensor automatically adjusts for drift and calibration variations without requiring user intervention, thereby maintaining high reading accuracy while reducing operational complexity.

Inventive Principle:

Principle #25Self-service

3Productivity

If sensor positioning is performed correctly, then continuous monitoring is enabled, but spurious low readings occur during the first night post-positioning

Engineering Contradiction:

Improvecontinuous monitoring capabilityVSAvoidaccuracy of analyte readings

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The sensor is pre-calibrated in the laboratory before implantation, establishing an initial calibration curve that anticipates the sensor's response characteristics. This preliminary calibration action eliminates the need for post-implantation waiting periods and ensures immediate accurate readings by pre-compensating for any initial response delays.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The system dynamically adjusts operational parameters such as detection sensitivity and calibration curves based on real-time sensor performance and environmental conditions. This parameter adaptation allows the sensor to maintain high reading accuracy throughout the monitoring period, including during the first night post-positioning, without requiring user intervention.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

These sensors provide clinically accurate glucose data immediately after placement with minimal interruptions due to spurious readings, reducing the need for frequent calibrations and enabling continuous, reliable glucose monitoring.

Implementation Method 1

the determination of the blood glucose level using calorimetric, electrochemical, or photometric detection

Methodology Applied

Scientific EffectElectrochemical detection: Electrochemiluminescence

Implementation Method 2

sensors that include an antiglycolytic agent or precursor thereof... retarding glucose consumption by living cells

Methodology Applied

Scientific EffectAntiglycolytic action: Enzyme

Data Source

PatentUS8515518B2Analyte monitoring

Publication Date: 2013.08.20 ABBOTT DIABETES CARE INC

AI summary

Devices and methods for determining the concentration of an analyte are provided. Embodiments of the subject devices include analyte monitoring systems that include an analyte sensor capable of providing clinically accurate analyte data without a substantial time delay after operably positioning the sensor in a patient. Embodiments of the subject methods include operably positioning an analyte sensor in a patient and obtaining clinically accurate analyte data without a substantial time delay after the positioning. Also provided are systems and kits for use in analyte monitoring.