Analyte Sensor Membrane Low Temperature Sensitivity
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Solution Overview
Problem
Existing analyte monitoring systems face challenges in maintaining consistent sensor performance due to temperature sensitivity, leading to fluctuations in signal readings, which can affect the accuracy of continuous glucose monitoring in bodily fluids.
Innovation Solution
Incorporating specific polymers and crosslinkers into the membrane formulation of analyte sensors to reduce temperature sensitivity, thereby stabilizing the sensor signal across a range of temperatures, including normal human body temperatures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional membrane materials are used in analyte sensors, then the sensor can detect analytes in bodily fluids, but the sensor signal fluctuates with temperature changes, reducing measurement accuracy
Solution Approach 1:
The patent modifies the membrane's physical-chemical parameters by incorporating polymers with specific glass transition temperatures and crosslinking densities. This changes the membrane's thermal response characteristics, reducing its sensitivity to temperature fluctuations and stabilizing the sensor signal across varying temperatures.
Solution Approach 2:
The patent creates a composite membrane material combining multiple polymers and crosslinkers with complementary properties. This composite structure leverages the thermal stability of certain polymers and the structural rigidity provided by crosslinking, achieving reduced temperature sensitivity while maintaining analyte permeability.
2Productivity
If the membrane is made more permeable to improve analyte detection, then the sensor response increases, but the membrane becomes more sensitive to temperature changes
Solution Approach 1:
The patent creates regions within the membrane with different properties - highly permeable regions for analyte transport and crosslinked regions for thermal stability. This local differentiation allows the membrane to simultaneously achieve high sensor response and low temperature sensitivity.
Solution Approach 2:
The patent optimizes the crosslinking density and polymer composition to achieve a specific balance between permeability and thermal stability. By carefully controlling these parameters, the membrane maintains high analyte flux while resisting temperature-induced structural changes.
Data Source
AI summary
Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane with low temperature sensitivity. The sensing layer is disposed on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.