Analyte Sensor Membrane Reduces Non-Constant Noise
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Solution Overview
Problem
Conventional self-monitoring blood glucose methods for diabetics are uncomfortable and inconvenient, leading to infrequent measurements that often result in delayed detection of hyperglycemic or hypoglycemic conditions, hindering timely insulin therapy decisions.
Innovation Solution
An electrochemical analyte sensor configured for continuous glucose monitoring with a membrane system that reduces noise contributions, allowing for accurate and sustained glucose level detection, minimizing non-analyte-related signal interference and providing a high signal-to-noise ratio for extended periods.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional self-monitoring blood glucose methods are used, then measurement simplicity is maintained, but measurement frequency is insufficient leading to delayed detection of glucose conditions
Solution Approach 1:
The patent replaces manual finger-pricking mechanical methods with an implantable electrochemical sensor system that continuously monitors glucose levels automatically, eliminating the need for repeated manual operations while enabling sustained high-frequency measurement
2Measurement precision
If continuous glucose monitoring is implemented, then measurement precision is improved, but signal noise from non-analyte-related components increases
Solution Approach 1:
The patent extracts and removes non-constant noise components from the sensor signal through electronic filtering and signal processing techniques, separating the harmful noise from the useful analyte signal to maintain high measurement precision
Solution Approach 2:
The patent changes the temporal characteristics of the signal by applying filtering operations that transform the noise profile, reducing the impact of non-constant noise while preserving the analyte-related signal components
3Stability of the object's composition
If sensor break-in period is extended, then signal stability is improved, but time to achieve accurate measurement increases
Solution Approach 1:
The patent performs preliminary calibration and signal characterization during a reduced break-in period, establishing baseline parameters in advance that enable accurate measurements to be achieved more quickly than conventional sensors
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sensor enables continuous, accurate glucose monitoring with the analyte-related component contributing at least 80% of the signal, reducing the impact of non-constant noise to less than 20%, facilitating timely and informed insulin therapy decisions.
Implementation Method 1
the membrane system is configured to inactivate at least one non-constant noise-causing electroactive species formed in a metabolic process of the host
Implementation Method 2
at least one electrode configured to measure an analyte concentration substantially continuously; and electronics configured to provide a signal measured at the electrode
Implementation Method 3
the membrane system comprises glucose oxidase
Implementation Method 4
the membrane system comprises glucose oxidase
Data Source
AI summary
Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.