Analyte Sensor Membrane Reduces Non-Constant Noise
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Solution Overview
Problem
Conventional self-monitoring blood glucose (SMBG) methods for diabetics are uncomfortable and inconvenient, leading to infrequent measurements, which can result in delayed detection of hyperglycemic or hypoglycemic conditions, hindering timely insulin therapy decisions.
Innovation Solution
An electrochemical analyte sensor configured for continuous glucose monitoring, featuring a membrane system that reduces noise contributions from non-constant, non-analyte-related components, allowing for accurate and sustained glucose level detection, with a signal contribution of analyte-related components exceeding 80% over extended periods.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional SMBG methods are used, then the measurement process is simple, but the measurement frequency is too low leading to delayed detection of glycemic conditions
Solution Approach 1:
The patent replaces the mechanical finger-pricking SMBG method with an implantable electrochemical sensor system that continuously monitors glucose levels in interstitial fluid, eliminating the need for repeated manual blood sampling while enabling continuous high-frequency measurements
Solution Approach 2:
The patent uses interstitial fluid as an intermediary medium to indirectly measure blood glucose levels, allowing continuous monitoring without direct blood sampling, thereby improving measurement frequency while maintaining patient comfort
2Measurement precision
If continuous monitoring is implemented, then measurement precision is improved, but noise from non-constant non-analyte-related components affects signal quality
Solution Approach 1:
The patent extracts and removes noise-causing interfering species from the sensor signal through selective chemical reactions and filtration techniques, separating the analyte-related signal from non-constant noise components to improve measurement precision
Solution Approach 2:
The patent changes the electrochemical parameters of the sensor system, including applied potential and reaction conditions, to optimize the detection of analyte-related signals while minimizing the impact of non-constant noise from interfering species
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sensor provides reliable, continuous glucose monitoring with minimal noise interference, enabling diabetics to make informed insulin therapy decisions in a timely manner, reducing the risk of dangerous glycemic events.
Implementation Method 1
the sensor is configured such that the substantially non-constant non-analyte related component does not substantially contribute to the signal, after sensor break-in
Implementation Method 2
at least one electrode configured to measure an analyte concentration substantially continuously
Data Source
AI summary
Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.