Continuous Calibration of Implantable Analyte Sensors
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Solution Overview
Problem
Continuous glucose monitoring systems experience gaps in service during sensor replacements and require laborious, error-prone calibration processes, often necessitating multiple capillary blood glucose measurements, which can lead to inaccurate readings due to transient sensitivity changes.
Innovation Solution
Implementing a method and system where short-term sensors are calibrated based on data from prior sensors during overlap periods, allowing for continuous monitoring without interruptions and reducing the need for additional capillary blood glucose values, by correlating and transferring calibration data between sensors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If short-term analyte sensors are used for continuous monitoring, then the sensor can be replaced periodically, but service gaps occur during replacement when analyte monitoring is interrupted
Solution Approach 1:
A second sensor is implanted before the first sensor is removed, creating an overlap period where both sensors are active. This preliminary placement ensures that monitoring continues without interruption during the transition between sensors.
Solution Approach 2:
The system maintains continuous analyte monitoring by having overlapping sensor periods where both the first and second sensors are simultaneously implanted and functional, eliminating any gap in the monitoring service.
2Measurement precision
If in-vivo calibration is performed for each newly implanted sensor using capillary blood glucose values, then the sensor can be calibrated to patient-specific conditions, but the process is laborious, time-consuming, and error-prone requiring multiple measurements
Solution Approach 1:
The second sensor is calibrated during the overlap period when the first sensor is already calibrated and providing accurate reference data. This preliminary calibration using the first sensor's data eliminates the need for time-consuming capillary blood glucose measurements for the second sensor.
Solution Approach 2:
The calibration data from the first sensor is copied and applied to the second sensor during the overlap period. Instead of performing new calibration measurements, the system uses the existing calibration from the first sensor to establish the second sensor's readings, significantly reducing calibration time and effort.
3Loss of time
If calibration is performed early in the sensor lifetime, then the sensor can be calibrated quickly, but transient sensitivity changes (early sensitivity attenuation) cause inaccurate readings at later time points
Solution Approach 1:
The second sensor is calibrated during the overlap period when the first sensor has already passed through its transient sensitivity changes and is providing stable, accurate reference data. This timing ensures that the calibration is performed when the reference sensor is at its most accurate state.
Solution Approach 2:
The system uses the first sensor's established calibration and stable readings as feedback to verify and adjust the second sensor's calibration during the overlap period, ensuring accuracy despite transient sensitivity changes in either sensor.
4Measurement precision
If multiple capillary blood glucose measurements are taken for calibration, then calibration accuracy is improved, but the process becomes more invasive and error-prone
Solution Approach 1:
Instead of taking multiple invasive capillary blood glucose measurements, the system copies the calibration data from the first sensor during the overlap period. This approach achieves accurate calibration without the need for repeated fingersticks, reducing patient discomfort and potential for user error.
Solution Approach 2:
The first sensor serves as an intermediary that provides reference calibration data for the second sensor. Rather than directly measuring capillary blood glucose multiple times, the system uses the first sensor's established calibration as a mediator to calibrate the second sensor, reducing invasive measurements.
Data Source
AI summary
Method and system for providing continuous calibration of analyte sensors includes calibrating a first sensor, receiving data associated with detected analyte levels from the first sensor, and calibrating a second sensor based on a predetermined scaling factor and data associated with detected analyte levels from the first sensor, is disclosed.