Analyte Sensors Conductive Particles Reagent Distribution
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Solution Overview
Problem
Existing glucose sensors face challenges with non-uniform distribution of detection reagents, leading to decreased accuracy and response times, particularly at high glucose concentrations, due to preferential deposition of reagents at the sides of the sample chamber during drying.
Innovation Solution
Incorporating conductive particles, such as microparticles or carbon nanopowder, into the detection reagent solution to ensure uniform distribution of analyte detection reagents on the working electrode surface, thereby preventing interference from red blood cells and enhancing the effective surface area.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If detection reagent solution is applied to the working electrode surface, then the reagents are deposited on the electrode, but the reagents deposit preferentially at the sides of the sample chamber resulting in non-uniform distribution
Solution Approach 1:
Conductive particles are introduced as an intermediary substance within the detection reagent solution. These particles serve as a mediator that influences the deposition pattern of the reagents, preventing preferential side deposition and ensuring uniform distribution across the working electrode surface during the drying process.
Solution Approach 2:
The physical and chemical parameters of the detection reagent solution are modified by incorporating conductive particles. This changes the rheological properties and deposition behavior of the solution, transforming the non-uniform deposition pattern into a uniform one as the solution dries on the electrode surface.
2Measurement precision
If conventional sensors are used, then the structure is simple, but the response time is slow and accuracy decreases at high glucose concentrations
Solution Approach 1:
The detection reagent solution is formulated as a composite material containing conductive particles mixed with the reagents. This composite structure provides both the functional detection capability and the uniform distribution property, enabling improved accuracy and faster response times simultaneously through the synergistic effects of the composite components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach results in improved uniformity of reagent distribution, increased accuracy, and faster response times by preventing reagent deposition at the sides of the sample chamber, ensuring complete reaction with analytes and reducing interference from sample components.
Implementation Method 1
Incorporating conductive particles, such as microparticles or carbon nanopowder, into the detection reagent solution to ensure uniform distribution of analyte detection reagents on the working electrode surface
Implementation Method 2
increased effective working electrode surface area
Implementation Method 3
electrochemical biosensors, including those that comprise a glucose sensor that is adapted to determine the concentration of an analyte in a bodily fluid
Data Source
AI summary
Provided are sensors for determining the concentration of an analyte in a sample fluid. In certain embodiments, the sensors include conductive particles and exhibit improved uniformity of distribution of one or more sensing chemistry components, increased effective working electrode surface area, and/or reduced entry of interfering components into a sample chamber of the sensor. Methods of using and manufacturing the sensors are also provided.