Automatic Analyzer Contamination Detection via Photometric Parameter Difference
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Solution Overview
Problem
Existing automatic analyzers for immunological agglutination reactions face challenges in accurately determining measurement results due to contamination from foreign substances, which can lead to unreliable analysis outcomes.
Innovation Solution
An automatic analyzer system that includes a dispensing section, reaction section, photometry section, analysis section, storage section, extraction section, and determination processing section, which captures images of reaction containers, calculates photometric parameters, and determines the validity of measurement results by comparing differences between maximum and minimum values of these parameters, thereby identifying and correcting for contamination effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If image capturing means is used to determine reaction results, then automation and efficiency are improved, but measurement precision deteriorates due to contamination from foreign substances
Solution Approach 1:
The system performs preliminary checks by capturing images of the reaction containers before final result determination. Multiple images are captured and analyzed to detect foreign substances or contamination before the final measurement is made, allowing preventive correction of potential errors
Solution Approach 2:
The system implements feedback mechanisms where captured images are analyzed to generate information about foreign substances or contamination. This feedback is then used to adjust or correct the measurement process, ensuring that final results are not compromised by contamination
2Measurement precision
If multiple checks are performed to detect foreign substances, then measurement precision is improved, but device complexity increases
Solution Approach 1:
The image capturing means serves multiple functions: it captures images for reaction result determination, detects foreign substances, and provides feedback for process correction. This multi-functionality reduces the need for separate dedicated checking devices, thereby limiting the increase in device complexity
Solution Approach 2:
The system uses its own image capturing and processing capabilities to detect and correct contamination issues, rather than requiring entirely separate checking systems. The analysis section processes the captured images to identify foreign substances and triggers appropriate corrections using the system's existing components
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach ensures reliable measurement results by accurately distinguishing between valid and invalid measurements, reducing errors caused by foreign substances and improving the reliability of analysis outcomes.
Implementation Method 1
capturing an image of the inside of each of the reaction containers
Implementation Method 2
photometry section for capturing an image of the inside of each of the reaction containers
Data Source
AI summary
Using a microplate having wells for the dispensing and reaction of a sample including blood and a reagent, an automatic analyzer captures an image of whether reactions have occurred inside the wells and performs analysis, the automatic analyzer comprising: a section for, with captured images obtained by capturing images of the inside of the wells corresponding to categories, calculating photometric parameters of the images, evaluating whether a measurement result based on the images is negative for each test, and analyzing characteristic information of the sample; a section for matching and storing characteristic information of samples and measurement results; a section for extracting a photometric parameter of a measurement result judged as negative; and a section for calculating a difference between maximum and minimum values of an extracted photometric parameter, determining whether a measurement is valid using the difference, and adding a result of the determination to characteristic information.