Anastomotic Device Projections Control Tissue Necrosis

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Solution Overview

Problem

Existing anastomotic devices for joining hollow lumens or viscera face issues such as ischemic necrosis, device slippage, incomplete tissue maturation, and potential intestinal occlusion due to compression forces that are not reliably controlled, leading to complications like peritonitis and intestinal perforation.

Innovation Solution

An anastomotic device with a main tubular body comprising sets of radial, proximal, and distal projections that secure the connection between lumens without compressive force, allowing controlled necrosis and maturation, featuring a design that prevents device slippage and ensures secure placement until removal after 90 days, using a superelastic titanium-nickel alloy for enhanced performance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If compression force is applied to induce tissue necrosis, then tissue maturation occurs, but device slippage and incomplete maturation control occur

Engineering Contradiction:

Improvetissue maturation controlVSAvoiddevice placement stability

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The device divides the compression function into separate segments: proximal and distal engagement arms provide anchoring without compression, while intermediate radial elements apply localized compression for controlled necrosis. This segmentation allows independent optimization of each function.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

Different portions of the device have different functional properties: the proximal and distal arms are designed for mechanical engagement and anchoring, while the intermediate radial elements are designed to apply compression force for tissue necrosis. This local differentiation resolves the contradiction between stability and controlled compression.

Inventive Principle:

Principle #3Local quality

2Duration of action of moving object

If device is designed to fall into intestine after necrosis, then device can be removed, but intestinal obstruction and perforation risks occur

Engineering Contradiction:

Improvedevice retention timeVSAvoidintestinal obstruction risk

Core Design Contradiction:

Duration of action of moving objectVSObject-affected harmful factors

Solution Approach 1:

The device uses shape memory alloy material that changes its mechanical properties based on temperature. At body temperature, the device maintains structural integrity to prevent obstruction. After the intended retention period, controlled dissolution or shape change allows safe removal, eliminating the obstruction risk.

Inventive Principle:

Principle #35Parameter changes

3Length of moving object

If device elongation is limited in catheter, then device fits in delivery system, but placement precision and maneuverability decrease

Engineering Contradiction:

Improvedevice compressed lengthVSAvoidplacement precision

Core Design Contradiction:

Length of moving objectVSManufacturing precision

Solution Approach 1:

The device transitions from a compressed dynamic state during delivery to an expanded functional state at the implantation site. The shape memory alloy enables controlled expansion after deployment, providing both catheter compatibility and placement precision through the phase transition.

Inventive Principle:

Principle #15Dynamics

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The device ensures secure gastrointestinal connection, controlled tissue necrosis, and reliable removal after maturation, reducing the risk of complications like peritonitis and intestinal occlusion, while allowing for precise placement and high elongation to facilitate endoscopic procedures.

Implementation Method 1

using a superelastic titanium-nickel alloy for enhanced performance

Methodology Applied

Scientific EffectSuperelasticity: Pseudoelasticity

Implementation Method 2

comprising a tube made of interlaced shape-memory wires

Methodology Applied

Scientific EffectShape memory effect: Shape Memory Alloy

Data Source

PatentEP3027123B1Anastomotic device for joining lumens or viscera to each other

Publication Date: 2019.02.13 COUSIN BIOTECH R L

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Figure 3~4A
Figure 4B~5

AI summary

The invention relates to an anastomotic device for joining lumens or hollow viscera, able to be deployed on the surface of two superimposed adjacent lumens, said device comprising a main tubular body with a longitudinal axis (L), having first and second open ends as well as opposite outer and inner faces, said main tubular body comprising at least three columns of loops and at least three rows of loops. Characteristically, said tubular body comprises sets of radial, proximal and distal projections extending said tubular body along at least one depth (E) respectively on the periphery of the first and second ends, said distal and proximal plays being separated by a minimum inner distance (D), and comprises a set of intermediate radial projections extending from said body along at least one depth (e) and arranged between the sets of radial, proximal and distal projections, in that (e) is less than (E), and in that the minimum inner distance (D) is determined so as to receive two adjacent superimposed lumens.