Andrographis Composition with Phosphoryl Ethanol Amine for Lower Toxicity

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Solution Overview

Problem

Existing compositions of Andrographis paniculata for oncological therapies face toxicity issues at high concentrations and long-term administration, particularly affecting normal cells while tumor cells develop resistance to multiple drugs.

Innovation Solution

A composition combining 10 to 30% Andrographis paniculata with 70 to 90% phosphoryl ethanol amine, optionally with calcium and magnesium carbonates, to enhance efficacy against tumor cells without harming normal cells.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If high concentrations of Andrographis paniculata are used, then antitumor activity is improved, but toxicity to normal cells increases

Engineering Contradiction:
Improveantitumor activityVSAvoidtoxicity to normal cells
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the concentration parameters by formulating a composition with 10-30% Andrographis paniculata extract and 70-90% phosphoryl ethanol amine, optimizing the ratio to achieve effective antitumor activity while reducing toxicity to normal cells

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

Phosphoryl ethanol amine acts as an intermediary carrier that enhances the bioavailability and pharmacokinetics of andrographolide, allowing lower concentrations of the active principle to achieve the same therapeutic effect with reduced toxicity

Inventive Principle:
Principle #24Intermediary (Mediator)

2Duration of action of moving object

If long-term administration of A. paniculata is used, then therapeutic effect is improved, but cumulative toxicity increases

Engineering Contradiction:
Improveduration of therapyVSAvoidcumulative toxicity
Core Design Contradiction:
Duration of action of moving objectVSObject-affected harmful factors

Solution Approach 1:

The patent modifies the chemical parameters by conjugating andrographolide with phosphoryl ethanol amine, creating a derivative with improved safety profile for long-term administration while maintaining therapeutic efficacy

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

Phosphoryl ethanol amine serves as a protective intermediary that reduces the toxic metabolic pathways of andrographolide, enabling safe long-term use through modified pharmacokinetics

Inventive Principle:
Principle #24Intermediary (Mediator)

3Device complexity

If A. paniculata is used alone, then simplicity of composition is improved, but efficacy against drug-resistant tumor cells is insufficient

Engineering Contradiction:
Improvecomposition simplicityVSAvoidefficacy against resistant tumor cells
Core Design Contradiction:
Device complexityVSReliability

Solution Approach 1:

The patent creates a composite pharmaceutical composition combining andrographolide with phosphoryl ethanol amine, where the synergistic interaction between components enhances efficacy against drug-resistant tumor cells while maintaining reasonable compositional simplicity

Inventive Principle:
Principle #40Composite materials

Data Source

PatentUS12364726B2Composition for obtaining a natural bioactive for oncologic therapies
Publication Date: 2025.07.22 MEY ANGELICA MACHADO

AI summary

The present invention refers to a composition for obtaining a natural bioactive for oncologic therapies based on Andrographis paniculata, whose excipient is phosphoryl ethanol amine, and optionally carbonates. The function of the composition is to assist treatments of several types of cancer, and it may be administered as an auxiliary adjuvant in oncologic therapies. Since it consists of diterpenoids, flavonoids and polyphenols as the main bioactive components, it has an anti-inflammatory, antiviral, antibacterial, antioxidant, antiparasitic, antispasmodic, antidiabetic, antipyretic, nematocidal, immunomodulatory and immunostimulatory action. The composition for obtaining a natural bioactive for oncologic therapies comprises: Active principle: Andrographis paniculata, and Excipient: phosphoryl ethanol amine. Optionally, the excipients are comprised of: Phosphoryl ethanol amine-Calcium Carbonate; and Magnesium Carbonate.