Aneurysm Closure Clip With Bioremodelable Seal
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Solution Overview
Problem
Existing endovascular treatments for aneurysms face challenges in effectively reducing pressure on the vessel walls due to blood flow, as embolization coils may not adequately prevent further enlargement of the aneurysm.
Innovation Solution
An aneurysm closure clip with a self-expanding frame, featuring winged elements and a seal element made from bioremodelable materials, is introduced to securely engage the vessel wall and reduce pressure by forming a barrier between the aneurysm and the rest of the vessel, facilitated by a guide bar for delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If embolization coils are used to occlude blood flow into the aneurysm, then the aneurysm can be treated without open surgery, but the pressure exerted by blood flow onto the coil may cause the aneurysm to continue enlarging
Solution Approach 1:
The closure device is divided into distinct functional segments: a seal element for occluding the aneurysm, winged elements for anchoring to the vessel wall, and a guide bar for delivery control. This segmentation allows each component to perform its specific function effectively, with the seal element directly addressing the pressure control issue while the winged elements provide stable anchoring.
Solution Approach 2:
The seal element acts as an intermediary between the blood flow and the aneurysm, creating a barrier that redirects blood flow away from the aneurysm sac. This intermediary structure prevents direct pressure transmission to the aneurysm wall, solving the pressure control problem while maintaining the endovascular approach.
2Reliability
If a closure device with winged elements is used to anchor to the vessel wall, then the device can securely engage the vessel, but the device complexity increases
Solution Approach 1:
The winged elements are integrated directly into the frame structure of the closure device, merging the anchoring function with the structural support function. This combination reduces the need for separate anchoring components while providing secure vessel wall engagement through the winged geometry that can embed into the vessel wall.
Solution Approach 2:
The seal element is constructed as a flexible barrier that can conform to the irregular geometry of the aneurysm opening and vessel wall. This flexibility allows the seal element to create an effective barrier without requiring a rigid, complex structure, maintaining simplicity while achieving reliable sealing.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The closure clip effectively reduces pressure on the aneurysm, preventing further enlargement and potential rupture by securely anchoring and sealing the aneurysm, utilizing bioremodelable materials for integration with the vessel wall.
Implementation Method 1
a self-expanding frame having a proximal side and a distal side. The frame is configured to move between a collapsed state in which the proximal and distal sides are compressed for delivery and an expanded state in which the frame expands to engage the body vessel
Implementation Method 2
The seal element is adapted to form a barrier and separate the aneurysm from the rest of the body vessel... The seal element of the closure clip includes a material layer comprised of a bioremodelable material, such as an extracellular matrix (ECM)
Data Source
AI summary
An aneurysm closure clip along with a system and method for use by a physician in delivering the closure clip into the vasculature of a patient is disclosed. The closure clip delivery system comprises a delivery tube in the form of a catheter, a guide wire, and a detachable closure clip. The closure clip includes a proximal side and a distal side. The distal side comprises at least two winged elements that interact with the wall of the body vessel to hold the clip in place after delivery. The proximal side includes a seal element and a guide bar. The guide bar is in communication with the guide wire during delivery. The seal element forms a barrier between the aneurysm and the rest of the body vessel, thereby, reducing any pressure exerted on the aneurysm. The seal element and optionally the winged elements include a material layer comprised of bioremodelable material, such as an extracellular matrix material (ECM).