Aneurysm Closure Device with Bioremodelable Cover
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Solution Overview
Problem
Cerebral aneurysms continue to enlarge and rupture due to persistent blood flow into the aneurysm, which existing embolization coils fail to adequately address, leading to pressure on the aneurysm walls.
Innovation Solution
A closure device comprising a frame with wire lobes and a cover is deployed in the aneurysm neck to block blood flow, using a catheter for percutaneous insertion and expansion within the aneurysm, with the frame transitioning between collapsed and expanded states for delivery and deployment, and a bioremodelable cover to promote tissue remodeling and stable closure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If embolization coils are placed in the aneurysm, then the risk of aneurysm enlargement and rupture is reduced, but blood flow continues to enter the aneurysm and exert pressure on the coil and aneurysm walls
Solution Approach 1:
The patent extracts the blood flow blocking function from the embolization coil by introducing a separate flow diverter device. The flow diverter is a mesh structure that redirects blood flow away from the aneurysm sac, while the coil remains inside to provide structural support. This separation allows the coil to maintain aneurysm stability without bearing the full burden of flow redirection, thereby reducing pressure on the aneurysm walls.
Solution Approach 2:
The patent employs a composite structure combining embolization coils and a flow diverter device. The flow diverter acts as an outer scaffold that redirects blood flow, while the coil serves as an inner reinforcement element. This composite approach leverages the complementary strengths of both components: the flow diverter's ability to redirect flow and the coil's ability to provide structural support, thereby reducing wall pressure while maintaining aneurysm stability.
2Reliability
If a closure device with frame and cover is deployed to block blood flow, then aneurysm expansion and rupture are prevented, but device complexity increases compared to simple coil embolization
Solution Approach 1:
The closure device is segmented into distinct functional components: a frame structure that provides structural support and positioning, and a cover that blocks blood flow into the aneurysm. This segmentation allows each component to be optimized for its specific function while working together as an integrated system, achieving reliable aneurysm stabilization despite the increased structural complexity.
3Reliability
If the frame expands in the aneurysm neck to block blood flow, then blood flow blocking is achieved, but the delivery and deployment process becomes more complex
Solution Approach 1:
The frame is designed with dynamic properties, transitioning from a compressed delivery state to an expanded deployed state. During delivery, the frame is compressed within the catheter for easy insertion. Upon deployment, it expands radially to engage the aneurysm neck and block blood flow. This dynamic transformation simplifies the delivery process while ensuring effective blood flow blocking when deployed.
Solution Approach 2:
The frame is nested within the catheter during delivery, with the cover nested within or attached to the frame. This nested configuration allows the entire closure device to be delivered through a single catheter access point, simplifying the delivery procedure. Upon deployment, the components are sequentially deployed or simultaneously expanded to achieve blood flow blocking.
Data Source
AI summary
The present invention provides a closure device for blocking blood flow into an aneurysm. The closure device includes a frame for positioning the closure device in the aneurysm and a cover supported by the frame to block blood flow through the frame into the aneurysm. The present invention also provides a method of blocking blood flow into an aneurysm using the closure device of the present invention.