Aneurysm Occlusive Mesh With Electrolytic Detachment for Rapid Sealing
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Solution Overview
Problem
Conventional treatments for intracranial aneurysms, such as using platinum coils or flow diverters, face challenges with long-term recanalization and delayed thrombus formation, especially for aneurysms with wide necks or large volumes, and require antiplatelet therapy that may exacerbate hemorrhaging.
Innovation Solution
A treatment system with an electrolytically corrodible core wire and an occlusive member, which includes a conduit for delivering an embolic element, allows for precise deployment and detachment within the aneurysm sac, using electrolytic corrosion for controlled release, and an expandable mesh to form a stable seal at the aneurysm neck.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If platinum coils are used to treat intracranial aneurysms, then the aneurysm interior volume is occluded, but long-term recanalization occurs especially for aneurysms with wide necks and large interior volumes
Solution Approach 1:
The device combines an occlusive member made of electrocorrodible material with a non-electrocorrodible support structure. This composite construction allows the occlusive member to provide immediate occlusion while the support structure maintains long-term structural integrity and prevents recanalization, even in aneurysms with wide necks and large volumes.
Solution Approach 2:
The patent changes the material parameter of the occlusive member from non-degradable (traditional coils) to electrocorrodible material. This parameter change allows the occlusive member to be actively removed via electrolytic corrosion after serving its immediate occlusion purpose, preventing long-term recanalization while maintaining initial occlusion effectiveness.
2Speed
If flow diverters are deployed to treat intracranial aneurysms, then blood flow is redirected away from the aneurysm, but it takes weeks or months to form aneurysmal thrombus and significantly longer for full effect
Solution Approach 1:
The occlusive member is pre-positioned within the aneurysm interior volume before flow diverter deployment. This preliminary action provides immediate occlusion from the start, eliminating the waiting period required for thrombus formation that characterizes flow diverter treatment.
Solution Approach 2:
The occlusive member acts as an intermediary device that provides immediate mechanical occlusion while the flow diverter works to redirect blood flow. This intermediary approach bridges the time gap between immediate occlusion needs and the gradual effect of flow redirection.
3Ease of operation
If flow diverters are used to treat intracranial aneurysms, then blood flow is preferentially directed along the main channel, but antiplatelet therapy is required which may exacerbate hemorrhaging risk
Solution Approach 1:
The patent extracts the need for antiplatelet therapy from the treatment protocol by using an electrocorrodible occlusive member that can be actively removed. This eliminates the requirement for long-term antiplatelet medication that creates hemorrhaging risk, while still achieving effective aneurysm occlusion.
Solution Approach 2:
The occlusive member is designed to be temporarily placed within the aneurysm to provide immediate occlusion, then actively removed via electrolytic corrosion once the aneurysm is secured. This temporary placement and active removal strategy eliminates the need for ongoing antiplatelet therapy, thereby reducing hemorrhaging risk.
4Productivity
If an electrolytically corrodible occlusive member is used, then rapid aneurysm occlusion is achieved with reduced recanalization rates, but the device requires electrolytic corrosion mechanism for controlled release
Solution Approach 1:
The patent replaces traditional mechanical detachment mechanisms (such as shape memory alloys or mechanical release systems) with an electrolytic corrosion-based detachment mechanism. This substitution allows for controlled removal of the occlusive member through electrochemical reactions, providing a simpler and more reliable detachment method.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Facilitates rapid aneurysm occlusion with reduced recanalization rates and eliminates the need for antiplatelet therapy, providing immediate life-saving potential by enhancing the stability and speed of thrombus formation.
Implementation Method 1
an electrolytically corrodible core wire having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion
Data Source
Figure 1A
Figure 1B
Figure 1C~1D
AI summary
Systems and methods for treating an aneurysm in accordance with embodiments of the present technology include intravascularly delivering an occlusive member to an aneurysm cavity via an elongated shaft and transforming a shape of the occlusive member within the cavity. The method may include introduction of an embolic element to a space between the occlusive member and an inner surface of the aneurysm wall. In some embodiments, the elongated shaft is detachably coupled to a distal portion of the occlusive member.