Aneurysm Neck Occlusion Mesh With Embolic Filling for Rapid Closure
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Solution Overview
Problem
Conventional treatments for intracranial aneurysms, such as using platinum coils or flow diverters, face challenges with long-term recanalization and delayed thrombus formation, which can be critical when the risk of aneurysm rupture is high, and often require antiplatelet therapy that may exacerbate hemorrhaging.
Innovation Solution
A treatment system with an electrolytically corrodible core wire and an occlusive member, including a conduit and expandable mesh, is deployed within the aneurysm, where the occlusive member is detached electrolytically and expanded to form a seal at the aneurysm neck, with an embolic element filling the cavity to promote thrombus formation and tissue remodeling.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If platinum coils are used to treat intracranial aneurysms, then thrombus formation is induced and aneurysm closure is achieved, but long-term recanalization occurs especially in aneurysms with wide necks and large interior volumes
Solution Approach 1:
The treatment system segments the aneurysm treatment into two distinct components: an occlusive member (stent or mesh) that provides structural support and flow diversion at the aneurysm neck, and an embolic element (liquid embolic or particles) that fills the aneurysm cavity to promote thrombus formation. This segmentation allows each component to address specific aspects of the problem, with the occlusive member preventing recanalization by maintaining neck occlusion and the embolic element ensuring complete cavity filling.
Solution Approach 2:
The system combines different materials with complementary properties: the occlusive member is made of biocompatible metal alloys (such as nitinol or platinum) that provide structural integrity and radiopacity, while the embolic element uses liquid embolic materials (such as ethanolamines or cyanoacrylates) that rapidly polymerize to form stable thrombus. This composite approach leverages the strengths of each material type to achieve both immediate occlusion and long-term durability.
2Reliability
If flow diverters are deployed to cause blood to preferentially flow along the main channel, then aneurysm thrombus formation is promoted, but it takes weeks or months for full effect and antiplatelet therapy is required
Solution Approach 1:
The system performs preliminary action by immediately filling the aneurysm cavity with embolic material during the procedure itself, rather than relying solely on gradual thrombus formation over weeks or months. The liquid embolic is delivered through a catheter and rapidly polymerizes to occlude the aneurysm sac, providing immediate effect. The occlusive member is also deployed simultaneously to establish flow diversion from the outset, eliminating the delayed effect period associated with flow diverters alone.
Solution Approach 2:
The system changes the parameters of blood flow dynamics by using the occlusive member to create a physical barrier at the aneurysm neck, fundamentally altering flow patterns to achieve complete flow diversion. This is more aggressive than conventional flow diverters that rely on gradual endothelialization, and the effect is achieved immediately upon deployment rather than over time. The embolic material further modifies the parameters by physically occupying the aneurysm cavity and promoting rapid thrombus formation.
3Reliability
If flow diverters are used to treat aneurysms, then thrombus formation in the aneurysm is promoted, but antiplatelet therapy is required which may exacerbate hemorrhaging after initial rupture
Solution Approach 1:
The system extracts the requirement for antiplatelet therapy by using a different mechanism to achieve aneurysm occlusion. Instead of relying on flow diversion alone that requires antiplatelet therapy to prevent stent thrombosis, the system uses liquid embolic material that actively promotes thrombus formation within the aneurysm cavity. The occlusive member provides structural support and flow diversion without requiring antiplatelet therapy, as the embolic material ensures complete cavity occlusion that prevents recanalization without needing to prevent platelet aggregation in the parent vessel.
Solution Approach 2:
The system converts the potentially harmful effect of thrombus formation into a beneficial outcome by using liquid embolic material that rapidly polymerizes to form a stable thrombus within the aneurysm cavity. This controlled thrombus formation is localized to the aneurysm sac and prevents rupture, while the occlusive member ensures complete occlusion. The approach transforms the risk of thrombosis from a system-wide concern requiring antiplatelet therapy into a localized beneficial effect that secures the aneurysm without compromising systemic hemostasis.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach provides rapid aneurysm closure, reduces the risk of rupture, and avoids the need for antiplatelet therapy by facilitating immediate thrombus formation and endothelial tissue growth, enhancing treatment efficacy.
Implementation Method 1
an electrolytically corrodible core wire having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion
Data Source
AI summary
Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible core wire having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the core wire distal portion. A conduit extends along at least a portion of the core wire. The conduit has a lumen configured to pass an embolic element therethrough.