Aneurysm Neck Occlusion Member for Stable Intrasaccular Sealing
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Solution Overview
Problem
Current treatments for intracranial aneurysms, such as platinum coil placement and flow diverters, face challenges with long-term recanalization and the need for antiplatelet therapy, which can be risky, especially in cases with wide necks or large volumes, necessitating a more effective and immediate solution.
Innovation Solution
A method involving positioning an expandable occlusive member within the aneurysm and introducing an embolic element to deform the occlusive member, creating a stable seal at the neck, which provides structural support, diverts blood flow, and facilitates tissue remodeling, while also serving as a scaffold for thrombus formation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If platinum coils are disposed within the aneurysm interior volume, then thrombus formation is induced and aneurysm rupture risk is reduced, but long-term recanalization occurs especially in aneurysms with wide necks and large interior volumes
Solution Approach 1:
The occlusive member is deployed in advance to immediately seal the aneurysm neck, creating a preliminary barrier that prevents blood flow into the aneurysm interior. This preliminary action achieves immediate neck closure rather than waiting for thrombus formation, thereby preventing recanalization while still allowing time for thrombus development within the sealed aneurysm sac.
Solution Approach 2:
The treatment is divided into two functional components: the occlusive member that seals the neck and the embolic material that fills the interior volume. This segmentation allows the neck closure function to be performed immediately by the occlusive member while the embolic material provides additional security against recanalization, addressing both the immediate and long-term occlusion requirements.
2Reliability
If flow diverters are deployed to cause blood to preferentially flow along the main channel, then aneurysm thrombus formation occurs, but it takes weeks or months to form thrombus and significantly longer for endothelial coverage
Solution Approach 1:
The occlusive member performs the critical neck sealing action immediately upon deployment, rather than waiting for the slow process of thrombus formation and endothelialization that characterizes flow diverter treatment. This preliminary neck closure provides immediate protection against rupture while the slower biological processes complete the occlusion.
Solution Approach 2:
The invention replaces the reliance on slow biological processes (thrombus formation and endothelialization) with an immediate mechanical action (occlusive member deployment) to achieve neck closure. This mechanical substitution provides immediate occlusion effect rather than waiting weeks or months for biological healing.
3Reliability
If flow diverters are used to treat aneurysms, then thrombus formation in the aneurysm is promoted, but antiplatelet therapy is required which increases risk of re-rupture after initial rupture
Solution Approach 1:
The invention extracts the critical occlusion function from the flow diverter device and concentrates it in the occlusive member deployed at the aneurysm neck. By taking out the essential neck sealing function and performing it immediately with the occlusive member, the system eliminates the need for flow diverters and their associated antiplatelet therapy requirements, thereby reducing re-rupture risk.
Solution Approach 2:
The occlusive member performs preliminary neck closure before any thrombus formation occurs, eliminating the need for antiplatelet therapy that would be required with flow diverters. This preliminary mechanical sealing provides immediate protection without the harmful side effects of antiplatelet medications.
4Ease of operation
If conventional vascular surgery is performed with microcatheter coil placement, then the procedure is minimally invasive, but recanalization occurs in cases with wide necks and large interior volumes
Solution Approach 1:
The invention merges the minimally invasive delivery approach with the immediate mechanical occlusion effect of the expandable occlusive member. The occlusive member is delivered through a catheter system (maintaining minimally invasive access) but provides immediate neck sealing and recanalization prevention (improving occlusion stability), combining the advantages of both approaches.
Solution Approach 2:
The occlusive member transitions from a compressed delivery state to an expanded deployed state within the aneurysm, dynamically changing its configuration to achieve the occlusion effect. This dynamic transformation allows the device to be delivered minimally invasively while providing immediate and stable occlusion upon deployment.
Data Source
AI summary
Systems and methods for treating an aneurysm in accordance with embodiments of the present technology include intravascularly delivering an occlusive member to an aneurysm cavity and deforming a shape of the occlusive member via introduction of an embolic element to a space between the occlusive member and an inner surface of the aneurysm wall.