Expandable Aneurysm Occlusion Member for Stable Neck Sealing
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Solution Overview
Problem
Current treatments for intracranial aneurysms, such as platinum coil placement and flow diverters, face challenges with long-term recanalization and the need for antiplatelet therapy, which can be risky, especially after aneurysm rupture, highlighting the need for innovative solutions to promptly and effectively treat and prevent re-rupture.
Innovation Solution
A method involving an expandable occlusive member positioned within the aneurysm cavity, where an embolic element is introduced to transform the occlusive member from a first expanded state to a second state, forming a stable seal at the aneurysm neck, using a mesh or braid structure that self-expands and is deformed to ensure complete filling and occlusion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If platinum coils are disposed within the aneurysm interior volume, then thrombus formation is induced and aneurysm closure is promoted, but long-term recanalization occurs especially in aneurysms with wide necks and large interior volumes
Solution Approach 1:
The flow diverter stent is deployed in advance to establish immediate blood flow redirection away from the aneurysm sac, creating preliminary conditions for thrombus formation before coil embolization is performed. This preliminary flow diversion ensures that even in wide-necked aneurysms, blood is channeled through the stent struts, preventing early recanalization and providing a stable framework for subsequent thrombus development.
2Reliability
If flow diverters are deployed to cause blood to preferentially flow along the main channel, then aneurysmal thrombus formation is promoted, but it takes weeks or months for full effect and antiplatelet therapy is required
Solution Approach 1:
The invention combines flow diverter stent deployment with coil embolization into a single integrated procedure. The flow diverter stent is positioned first to establish immediate flow redirection, followed by coil placement within the aneurysm sac while the stent maintains flow diversion. This merging of techniques allows the coil to immediately occlude the aneurysm interior while the stent prevents recanalization, achieving both immediate and sustained occlusion effects in one procedure, eliminating the weeks-to-months delay associated with flow diverters alone.
3Reliability
If flow diverters are used to treat aneurysms, then thrombus formation in the main channel is prevented with antiplatelet therapy, but this therapy is contraindicated after initial aneurysm rupture due to high re-rupture risk
Solution Approach 1:
Instead of using antiplatelet therapy to prevent thrombus formation in the main channel (the conventional approach), the invention inverts the strategy by using the flow diverter stent structure itself to mechanically guide blood flow through its struts, creating controlled turbulence and flow patterns that promote thrombus formation within the aneurysm sac without requiring systemic antiplatelet therapy. This inversion allows effective aneurysm occlusion while avoiding the hemorrhage risk associated with antiplatelet medications in ruptured aneurysms.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach provides immediate and sustained occlusion of the aneurysm, reducing the risk of re-rupture and recanalization, while avoiding the limitations of traditional methods by ensuring a complete seal and promoting tissue remodeling without the need for prolonged antiplatelet therapy.
Implementation Method 1
releasing an occlusive member from the elongated shaft while the distal end of the elongated shaft is positioned within the aneurysm cavity such that the occlusive member self-expands to assume a first expanded state
Implementation Method 2
delivering an embolic element between the occlusive member and the aneurysm wall to transform the occlusive member into a second expanded state in which the occlusive member defines a second interior volume less than the first interior volume
Data Source
AI summary
Systems and methods for treating an aneurysm in accordance with embodiments of the present technology include intravascularly delivering an occlusive member to an aneurysm cavity and deforming a shape of the occlusive member via introduction of an embolic element to a space between the occlusive member and an inner surface of the aneurysm wall.