Aneurysm Occlusion Member With Embolic Delivery for Stable Neck Sealing
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Solution Overview
Problem
Current treatments for intracranial aneurysms, such as platinum coil placement and flow diverters, face challenges with long-term recanalization and the need for antiplatelet therapy, which can be risky, especially after aneurysm rupture, highlighting the need for a more effective and immediate solution to prevent rupture and re-rupture.
Innovation Solution
A treatment system comprising an electrolytically corrodible core wire with an occlusive member and a conduit for delivering an embolic element, which self-expands within the aneurysm to form a stable seal at the neck, using an electrolytic detachment mechanism for reliable deployment and bioabsorbable materials for tissue remodeling.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If platinum coil is disposed within the aneurysm to induce thrombus formation, then the aneurysm should be occluded to reduce rupture risk, but long-term recanalization occurs especially in aneurysms with wide necks and large interior volumes
Solution Approach 1:
The flow diverter stent is deployed in advance to redirect blood flow away from the aneurysm sac before thrombus formation occurs. This preliminary flow redirection creates optimal conditions for subsequent thrombus development while maintaining aneurysm occlusion stability, preventing recanalization in wide-necked aneurysms
2Reliability
If flow diverter is deployed to cause blood to stagnate within the aneurysm and form thrombus, then the aneurysm neck should close over time, but it takes weeks or months for full effect and requires antiplatelet therapy
Solution Approach 1:
The device combines the flow diversion function of a stent with an integrated occlusive element that actively promotes thrombus formation. This merging of functions accelerates the occlusion process from weeks/months to a much shorter timeframe while maintaining reliable aneurysm closure, eliminating the need for prolonged antiplatelet therapy
3Ease of operation
If flow diverter is used to treat the aneurysm, then blood flow is redirected along the main channel, but antiplatelet therapy is required which increases risk of re-rupture after initial rupture
Solution Approach 1:
The solution extracts and eliminates the requirement for antiplatelet therapy by using a device that achieves rapid, reliable occlusion through mechanical flow diversion and integrated occlusion. This removes the harmful side effect of re-rupture risk associated with antiplatelet medications while maintaining procedural simplicity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution provides a faster and more stable occlusion of the aneurysm, reducing the risk of recanalization and eliminating the need for antiplatelet therapy, with the embolic element exerting uniform pressure to ensure a complete seal and promote endothelial growth, thus enhancing treatment efficacy and safety.
Implementation Method 1
an electrolytically corrodible core wire having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion
Data Source
AI summary
Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A treatment system for such treatment can include an electrolytically corrodible core wire having a proximal portion, a distal portion, and a detachment zone between the proximal portion and the distal portion. An occlusive member having a proximal hub is coupled to the core wire distal portion. A conduit extends along at least a portion of the core wire. The conduit has a lumen configured to pass an embolic element therethrough.