Angiogenic Factor Delivery for Vasculogenic Erectile Dysfunction
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Solution Overview
Problem
Current treatments for erectile dysfunction, particularly those targeting vasculogenic conditions, often fail to address the underlying causes and provide only temporary relief, with many patients experiencing little to no benefit from existing medications, and there is a need for improved diagnosis and treatment methods that can identify and alleviate vascular-related erectile dysfunction effectively.
Innovation Solution
The development of methods and systems for diagnosing and treating vasculogenic erectile dysfunction through imaging and assessment of vascular abnormalities, using angiogenic factors like FGF-1 to promote angiogenesis and increase blood flow to affected areas, combined with the use of medical devices for controlled release of these factors, and the application of extracellular matrix components to create a conducive environment for tissue repair.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If traditional medications (PDE-5 inhibitors) are used to treat erectile dysfunction, then temporary relief is achieved, but the underlying vascular causes are not addressed and long-term improvement is not sustained
Solution Approach 1:
The patent applies preliminary action by administering angiogenic factors (such as FGF-1, VEGF, or PDGF) before the erectile dysfunction episode occurs to stimulate the growth of new blood vessels and improve vascular health proactively. This preliminary vascular intervention addresses the underlying cause rather than providing temporary symptomatic relief, enabling long-term improvement in erectile function by building a more robust vascular network in advance.
2Reliability
If angiogenic factors are administered to promote angiogenesis, then blood flow to affected areas is increased and vascular health is improved, but the complexity of the treatment system increases
Solution Approach 1:
The patent uses an intermediary delivery system such as a bioresorbable scaffold or implantable device that releases angiogenic factors in a controlled manner. This intermediary carrier simplifies the treatment process by encapsulating the complex combination of growth factors (FGF-1, VEGF, PDGF) and releasing them progressively, reducing the need for multiple separate administrations and making the complex therapy more manageable and less invasive.
3Measurement precision
If imaging and assessment methods are used to diagnose vascular abnormalities, then targeted treatment can be achieved, but the cost and complexity of diagnosis increases
Solution Approach 1:
The patent segments the diagnostic process into multiple specialized components: Doppler ultrasound for blood flow assessment, MRI for anatomical visualization, and biochemical testing for vascular function. By dividing the comprehensive evaluation into these distinct, manageable segments, the system achieves high measurement precision in identifying vascular abnormalities while keeping each individual test simpler and more targeted, rather than requiring one complex all-encompassing diagnostic device.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These methods enable targeted and potentially long-term improvements in erectile function by enhancing blood flow and vascular health, offering a more effective treatment option for patients with vasculogenic erectile dysfunction, including those who do not respond to traditional medications.
Implementation Method 1
using angiogenic factors like FGF-1 to promote angiogenesis and increase blood flow to affected areas
Data Source
AI summary
Disclosed are devices, methods and surgical procedures for detecting, imaging, analyzing, diagnosing and/or treating vascular disorders and related conditions of the human and mammalian body in males and/or females. In particular embodiments, treatments include methods for imaging, analyzing and improving erectile dysfunction and related conditions and potentially increasing angiogenesis in response to specifically diagnosed conditions.