Angiogenin Lactoperoxidase Drink for Bone Density
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Solution Overview
Problem
Current methods for preventing and treating bone diseases such as osteoporosis, fracture, and arthritis are limited by low calcium absorption rates and side effects from existing medications, making it challenging to develop a safe and effective oral beverage for long-term consumption that promotes bone strength and prevents bone resorption.
Innovation Solution
A drink containing angiogenin and/or angiogenin hydrolysate in combination with lactoperoxidase and/or lactoperoxidase hydrolysate in specific mass ratios, added to a drink raw material and sterilized, which enhances bone density and strength when consumed in amounts of 200 ml or more per day.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If calcium salts or natural calcium products are added to strengthen bones, then bone strength is improved, but calcium absorption rate remains low (50% or less)
Solution Approach 1:
The patent introduces casein phosphopeptide as an intermediary substance that mediates between calcium and the intestinal absorption system. This peptide acts as a carrier that binds calcium and facilitates its transport across the intestinal barrier, thereby improving absorption efficiency without changing the calcium source itself.
Solution Approach 2:
The patent changes the chemical form of calcium delivery by combining it with casein phosphopeptide, creating a complex that has different absorption characteristics than pure calcium salts. This parameter change in the calcium delivery system transforms the absorption rate from 50% or less to significantly higher levels.
2Reliability
If calcium is absorbed into the body, then bone metabolism may be improved, but the effect is uncertain since affinity to bones differs according to form and nutritional ingredients
Solution Approach 1:
The patent modifies the chemical parameters of calcium delivery by using casein phosphopeptide complexes, which have demonstrated higher affinity for bone tissue and more reliable bone metabolism effects compared to conventional calcium forms.
Solution Approach 2:
The patent creates a composite substance combining calcium with casein phosphopeptide, where the peptide component enhances the bone-targeting ability and metabolic effectiveness of calcium, providing more predictable and reliable bone health outcomes.
3Strength
If existing bone-strengthening drugs (estrogen products, vitamin D3, bisphosphonates) are used to treat osteoporosis, then bone strength is improved, but side effects occur (buzzing in ear, headache, loss of appetite)
Solution Approach 1:
The patent employs food-grade ingredients (casein phosphopeptide and oligosaccharides) that are safe for long-term consumption, replacing pharmaceutical substances that provide bone strengthening effects but cause unacceptable side effects for chronic use.
Solution Approach 2:
The patent changes the mode of action from pharmacological intervention to nutritional supplementation, using substances that modulate bone metabolism through physiological pathways rather than drug-receptor interactions, thereby avoiding medication side effects.
4Strength
If existing bone-strengthening substances are added to food or drink, then bone strength may be improved, but safety, cost, and feasibility issues prevent current implementation
Solution Approach 1:
The patent uses casein phosphopeptide and oligosaccharides, which are naturally occurring or easily produced food-grade ingredients, replacing expensive or regulated pharmaceutical substances. These ingredients are safe for food addition and can be manufactured at scale without special approvals.
Data Source
AI summary
The invention relates to a drink includes angiogenin and/or angiogenin hydrolysate in an amount of more than 0.8 mg/100 ml and not more than 150 mg/100 ml, and lactoperoxidase and/or lactoperoxidase hydrolysate in the mass ratio to the angiogenin and/or angiogenin hydrolysate of 0.3 to 23.