Angiotensin-(1-7) Agonist for Cognitive Dysfunction
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Solution Overview
Problem
There is no effective pharmacological treatment for cognitive impairment or dysfunction associated with increased inflammatory cytokines and reactive oxygen species in the brain, particularly in conditions like congestive heart failure and postoperative cognitive dysfunction.
Innovation Solution
Administration of an angiotensin-(1-7) receptor agonist, which can be peptidic or non-peptidic, to treat cognitive dysfunction by reducing inflammation and oxidative stress, thereby improving cognitive function and memory in patients with conditions such as congestive heart failure, cardiovascular disease, and postoperative cognitive decline.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional pharmacological treatments are used for cognitive impairment, then existing symptom management may be provided, but no effective treatment exists for cognitive dysfunction associated with increased inflammatory cytokines and reactive oxygen species
Solution Approach 1:
The patent changes the pharmacological parameter from conventional antioxidants and anti-inflammatories to angiotensin-(1-7) receptor agonists, which specifically target the oxidative stress and inflammation pathways through a different mechanism of action, achieving effective treatment where conventional approaches failed
Solution Approach 2:
The angiotensin-(1-7) receptor agonist demonstrates multi-functionality by effectively treating cognitive dysfunction across multiple clinical conditions including congestive heart failure, postoperative cognitive dysfunction, and other conditions associated with increased inflammatory cytokines and reactive oxygen species, making it universally applicable
2Reliability
If angiotensin-(1-7) receptor agonist is administered to reduce inflammation and oxidative stress, then cognitive function and memory are improved, but the mechanism involves complex interaction with inflammatory cytokines and reactive oxygen species pathways
Solution Approach 1:
The angiotensin-(1-7) receptor agonist acts as an intermediary substance that mediates between the administered drug and the complex biological pathways, selectively activating Mas receptors to produce anti-inflammatory and antioxidant effects without requiring direct manipulation of multiple cytokine pathways
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The angiotensin-(1-7) receptor agonist effectively prevents, inhibits, or reverses cognitive dysfunction by reducing inflammatory cytokines and reactive oxygen species, improving cognitive function and memory in patients with associated clinical conditions, as demonstrated in preclinical models.
Implementation Method 1
administration of a Mas receptor agonist, such as angiotensin-(1-7) or a derivative or analog thereof
Implementation Method 2
activates Mas receptors to produce anti-inflammatory and antioxidant effects
Implementation Method 3
Administering a Mas receptor agonist... reduces the production and levels of inflammatory cytokines
Implementation Method 4
reduces the production and levels of reactive oxygen species
Data Source
AI summary
The present invention provides compositions and methods for treating cognitive impairment or dysfunction in a subject. In particular, the present invention provides a method for using a composition comprising an angiotensin-(1-7) receptor agonist to treat cognitive dysfunction or impairment that is due to a various clinical conditions including, but not limited to, those associated with increase in inflammation, cytokine production, increases in reactive oxygen species, changes in expression of brain inflammatory related genes and/or in the expression of genes involved in learning and memory within the central nervous system of a subject.