Angled Magnetic Stand Prevents Spike Phenomenon
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Solution Overview
Problem
Magnetic separation methods in biological substance extraction often suffer from the 'spike phenomenon' where magnetic beads are arranged in a needle shape, reducing separability and purity due to inappropriate magnetic field direction, leading to impurities being mixed with the extracted substance.
Innovation Solution
A magnetic stand and separation method where the magnetic poles face directions different from the container, and the magnetic field is angled such that when projected onto a plane including the container's axis, the angle formed is more than 0° and 90° or less, preventing the spike phenomenon and improving separability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the permanent magnet is disposed with N pole facing the container and S pole facing the opposite side, then the magnetic field can be applied to the container, but the magnetic beads are arranged in a needle shape (spike phenomenon) which reduces separability and purity
Solution Approach 1:
The patent changes the symmetric N-S pole arrangement to an asymmetric configuration where only one magnetic pole faces the container while the other pole is positioned at a different orientation. This asymmetric magnetic field arrangement prevents the magnetic beads from aligning in a needle shape, thereby eliminating the spike phenomenon and improving both separability and purity of the extracted biological substance.
Solution Approach 2:
The patent modifies the magnetic field parameters by changing the orientation and positioning of the magnetic poles. Specifically, it adjusts the angular relationship between the magnetic field lines and the container axis, and optimizes the distance between the magnetic pole and the container. These parameter changes prevent the formation of needle-shaped bead arrangements while maintaining effective magnetic field application.
2Power
If the magnetic beads are arranged in a needle shape, then the magnetic field is effectively applied, but solution is held between the magnetic beads which reduces separability and allows impurities to mix with the extracted substance
Solution Approach 1:
By implementing asymmetric magnetic pole arrangement, the patent creates an uneven magnetic field distribution that prevents magnetic beads from forming tight needle-shaped clusters. This asymmetric configuration maintains strong magnetic field application while creating gaps between beads that allow solution to drain properly, thereby improving separability and preventing impurity contamination.
3Productivity
If the direction of the magnetic field is not appropriate, then the magnetic separation can be performed, but the spike phenomenon occurs and washing efficiency and purity are lowered
Solution Approach 1:
The patent optimizes magnetic field parameters including the angle between magnetic field lines and container axis, and the distance from the magnetic pole to the container. By adjusting these parameters to specific ranges, the patent achieves rapid magnetic separation while preventing the spike phenomenon, thereby maintaining both high productivity and high washing efficiency with improved purity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This configuration enhances the separability of magnetic beads from the liquid, reducing residual liquid amounts and improving the purity of extracted biological substances by preventing the spike phenomenon, allowing for high-yield extraction of nucleic acids and other biological materials.
Implementation Method 1
a magnet provided on the base and having a magnetization that applies a magnetic field to the insertion hole
Implementation Method 2
a magnetic field generation device such as a magnetic stand... separating and collecting magnetic beads by a magnetic force
Data Source
AI summary
A magnetic stand includes: a base having an insertion hole into which a container is to be inserted, the insertion hole extending along a first axis; and a magnet provided on the base and having a magnetization that applies a magnetic field to the insertion hole. The magnet is disposed such that magnetic poles thereof face directions different from that of the container. When a plane including the first axis and determined such that a normal line of the plane is orthogonal to the first axis and passes through a center of the magnet is taken as a reference plane, and the magnetization is projected onto the reference plane, an angle formed by the first axis and the magnetization projected onto the reference plane is more than 0° and 90° or less.