Anhydrous Gibberellic Acid Solvent System for Hydrolysis Prevention
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Solution Overview
Problem
Gibberellin A3 (GA3) solutions in aqueous or aqueous-alcoholic solutions are prone to hydrolysis, limiting their concentration and stability, especially when attempting to achieve higher weight percentages in anhydrous form for agricultural applications.
Innovation Solution
Dissolving GA3 in an anhydrous solvent at elevated temperatures and allowing the solution to cool to room temperature results in stable anhydrous solutions with concentrations between 5 wt % and 15 wt % in solvents comprising isopropanol, with optional additions of methanol, ethanol, DMSO, n-propanol, or tetrahydrofurfuryl alcohol, maintaining stability even when cooled to −20° C.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If GA3 is dissolved in aqueous or aqueous-alcoholic solutions, then the solution is easier to prepare, but the solution becomes unstable and prone to hydrolysis
Solution Approach 1:
The patent changes the key parameter of solvent composition by using anhydrous alcohol instead of aqueous or aqueous-alcoholic solutions. This parameter change eliminates water from the system, preventing hydrolysis reactions and significantly improving the stability of GA3 while maintaining ease of preparation through simple dissolution in the anhydrous solvent.
Solution Approach 2:
The patent creates an inert environment by using anhydrous alcohol as the solvent, effectively excluding water from the solution system. This inert environment prevents hydrolysis reactions that would otherwise occur in aqueous solutions, thereby maintaining GA3 stability without complicating the preparation process.
2Quantity of substance
If the concentration of GA3 is increased in anhydrous form, then the effectiveness for agricultural applications is improved, but the solubility and stability are reduced
Solution Approach 1:
The patent achieves high GA3 concentrations (5-15 wt%) in anhydrous form by changing the solvent parameters to anhydrous alcohol conditions. This parameter change allows the system to maintain both high concentration and high stability simultaneously, as the anhydrous environment prevents hydrolysis even at elevated GA3 levels where aqueous solutions would become unstable.
3Quantity of substance
If the concentration of GA3 is increased in anhydrous form, then the effectiveness for agricultural applications is improved, but the crystallization tendency increases
Solution Approach 1:
The patent uses anhydrous alcohol as the solvent to change the physical-chemical parameters of the solution system. This parameter change allows high GA3 concentrations to be maintained in solution without crystallization, as the anhydrous environment fundamentally alters the solubility characteristics compared to aqueous systems, enabling stable high-concentration formulations.
4Reliability
If the solution is cooled to lower temperatures, then the stability is improved, but the solubility of GA3 is reduced
Solution Approach 1:
The patent changes the solvent parameter to anhydrous alcohol, which fundamentally alters the temperature-solubility relationship. In this anhydrous system, GA3 remains soluble at lower temperatures where it would otherwise crystallize from aqueous solutions, allowing the solution to be stored at refrigerated temperatures for enhanced stability without losing solubility or forming crystals.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method produces stable anhydrous GA3 solutions with concentrations up to 15 wt % in specific solvent combinations, enhancing their usability and stability for agricultural applications by preventing crystallization and maintaining solubility at lower temperatures.
Implementation Method 1
dissolving GA3 in an anhydrous solvent at elevated temperatures and allowing the solution to cool to room temperature results in stable anhydrous solutions
Data Source
AI summary
The present disclosure provides an anhydrous solution that includes between 5% and 15% w/w of gibberellic acid (GA3) in a solvent, where the solvent consists of: (a) isopropanol; (b) up to 10% w/w of methanol, ethanol, or a combination thereof; (c) up to 10% w/w of dimethyl sulfoxide (DMSO); and (d) up to 50% w/w of n-propanol, tetrahydrofurfuryl alcohol (THFA), or a combination thereof. The disclosure also provides methods of making such solutions.