Anhydrous Hydrogel for Cannabinoid Delivery
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Solution Overview
Problem
Current hydrogel-based drug delivery systems are limited by their water content, making them unsuitable for moisture-sensitive active agents and environments, and existing pain treatments for oral and dental pain often have ineffective side effects and opioid-related concerns.
Innovation Solution
Development of an anhydrous hydrogel composition combining biocompatible polymers like sodium carboxymethyl cellulose with anhydrous glycerin, incorporating effective amounts of cannabinoids such as CBD and menthol, which are resistant to moisture and maintain therapeutic efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If traditional hydrogel-based drug delivery systems are used, then high water content provides good biocompatibility and flexibility, but water sensitivity limits utility for moisture-sensitive active agents and environments
Solution Approach 1:
The patent changes the fundamental parameter of water content from high (traditional hydrogel) to low or absent (anhydrous), transforming the system from water-based to oil-based or solvent-free, thereby enabling compatibility with moisture-sensitive active agents while maintaining gel-like properties through alternative mechanisms
Solution Approach 2:
The patent creates a composite system combining biocompatible polymers with oils or other non-aqueous liquids to form an anhydrous hydrogel that exhibits both the desired moisture-free environment and the flexibility/biocompatibility typically associated with water-containing hydrogels
2Stability of the object's composition
If water is included in hydrogel to achieve flexibility similar to natural tissue, then physical properties improve, but reactivity to acids and bases increases and moisture sensitivity occurs
Solution Approach 1:
The patent changes the chemical composition parameter by removing water and replacing it with oils or non-aqueous liquids, thereby altering the chemical stability profile to resist acid-base reactivity while maintaining physical flexibility through the new solvent system
3Reliability
If opioid pain treatments are used for oral and dental pain, then pain relief is achieved, but unacceptable side effects and overuse concerns arise
Solution Approach 1:
The patent changes the active agent parameter from opioids to cannabinoids (such as CBD) combined with menthol, thereby maintaining pain relief efficacy while eliminating the harmful side effects and dependency concerns associated with opioid treatments
Solution Approach 2:
The patent creates a composite therapeutic formulation combining cannabinoids and menthol in an anhydrous hydrogel base, leveraging the synergistic effects of these ingredients to provide effective pain relief without the harmful properties of opioids
Data Source
AI summary
The present disclosure relates to compositions, including, hydrogel compositions useful as topical oral analgesics including cannabinoids and menthol.