Anhydrous Hydrogel Suppository for Veterinary Pain Relief

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Solution Overview

Problem

Current pain and inflammation treatments, particularly for oral and dental pain, are often ineffective and come with unacceptable side effects, and there is a growing concern about the overuse of opioid pain treatments. Additionally, traditional hydrogels are limited by their water content, which restricts their application in water-sensitive environments and is reactive to acids and bases.

Innovation Solution

A suppository composition comprising a biocompatible polymer, polyalcohol, cannabinoids, menthol, and an anesthetic, specifically using a stabilized menthol composition with undecylenic acid methyl ester or undecylenic acid, and benzocaine, formulated as an anhydrous hydrogel to provide effective pain relief and inflammation reduction without the aqueous limitations of traditional hydrogels.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If traditional hydrogels are used for drug delivery, then high water content provides good biocompatibility and flexibility, but water sensitivity limits utility in water-sensitive environments and creates reactivity to acids and bases

Engineering Contradiction:

Improveapplicability in water-sensitive environmentsVSAvoidreactivity to acids and bases

Core Design Contradiction:

Adaptability or versatilityVSStability of the object's composition

Solution Approach 1:

The patent removes water from the hydrogel composition to create an anhydrous form. This extraction of the problematic component (water) eliminates the reactivity to acids and bases while preserving the hydrogel's structural properties and drug delivery capabilities, enabling use in water-sensitive environments

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent changes the water content parameter from high (traditional hydrogels contain over 99.9% water) to zero (anhydrous hydrogels). This parameter change fundamentally alters the chemical stability and environmental compatibility of the hydrogel, resolving the contradiction between versatility and stability

Inventive Principle:

Principle #35Parameter changes

2Reliability

If opioids are used for pain treatment, then effective pain relief is achieved, but unacceptable side effects and overuse concerns arise

Engineering Contradiction:

Improvepain relief effectivenessVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent combines multiple active agents (cannabinoids, menthol, and anesthetics) in a single composite formulation. This composite approach provides effective pain relief through synergistic mechanisms while avoiding the severe side effects associated with opioid use, as each component contributes to pain management through different pathways

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent creates a non-opioid alternative that copies the pain relief function of opioids without using opioid compounds. By utilizing cannabinoids, menthol, and anesthetics, the formulation replicates the therapeutic effect of opioids while eliminating their harmful side effects and dependency risks

Inventive Principle:

Principle #26Copying

Data Source

PatentUS11344495B2Veterinary cannabinoid, menthol and anesthetic compositions and methods

Publication Date: 2022.05.31 GHALILI BABAK

AI summary

The present disclosure relates to compositions, including, hydrogel compositions useful as analgesics including cannabinoids, menthol and anesthetic in a composition formulated to be administrable to a non-human animal rectally as a suppository. The menthol component can be a stabilized menthol composition comprising menthol and at least one menthol stabilizer compound including undecylenic acid methyl ester, undecylenic acid or a salt of undecylenic acid.