Anhydrous Silver Citrate Hydrogel for Antimicrobial Protection

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Solution Overview

Problem

Existing methods require reconstitution of anhydrous silver dihydrogen citrate (SDC) into an aqueous solution for antimicrobial applications, which is inconvenient and may not be necessary for non-aqueous systems.

Innovation Solution

An anhydrous composition of silver dihydrogen citrate and citric acid is used directly in non-aqueous formulations, incorporated into various materials and surfaces without reconstitution, providing antimicrobial protection across a range of applications from medical devices to construction materials and water treatment.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If anhydrous silver dihydrogen citrate is reconstituted into an aqueous solution for antimicrobial applications, then the disinfectant achieves full antimicrobial activity, but the process becomes inconvenient and requires additional steps for preparation

Engineering Contradiction:
Improveantimicrobial activityVSAvoidconvenience of use
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The invention changes the physical state parameter of the silver dihydrogen citrate from anhydrous (dry powder) to a solubilized form within the hydrogel matrix. The hydrogel provides a controlled release mechanism where the active ingredient is gradually released in situ, eliminating the need for separate reconstitution steps while maintaining antimicrobial efficacy. This resolves the contradiction by transforming the delivery system rather than the active ingredient itself.

Inventive Principle:
Principle #35Parameter changes

2Ease of operation

If anhydrous silver dihydrogen citrate is used directly in non-aqueous formulations, then the ease of operation and convenience are improved, but the traditional method required reconstitution to ensure proper antimicrobial function

Engineering Contradiction:
Improveconvenience of useVSAvoidantimicrobial effectiveness
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The hydrogel acts as an intermediary carrier that bridges the gap between the anhydrous powder form and the aqueous environment needed for antimicrobial activity. The hydrogel matrix contains the anhydrous SDC and citric acid, and upon contact with moisture (wound exudate, ambient humidity), it solubilizes the active ingredients in situ. This intermediary approach allows direct application of the anhydrous formulation while ensuring reliable antimicrobial function through controlled solubilization.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention performs preliminary action by pre-combining the anhydrous silver dihydrogen citrate with citric acid in a hydrogel matrix during manufacturing. This pre-prepared composite material contains all necessary components for antimicrobial activity, and the hydrogel structure is designed to facilitate automatic solubilization when exposed to moisture. The preliminary formulation work eliminates the need for user-level reconstitution while guaranteeing proper chemical composition for effectiveness.

Inventive Principle:
Principle #10Preliminary action

3Reliability

If silver dihydrogen citrate is generated electrolytically in citric acid solution, then the antimicrobial composition is effective, but the process requires aqueous solution preparation and handling

Engineering Contradiction:
Improvedisinfectant effectivenessVSAvoidpreparation process complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The invention merges the generation process with the delivery system by incorporating the electrolytically generated silver dihydrogen citrate directly into a hydrogel matrix during manufacturing. Rather than separately preparing the aqueous solution and then applying it, the active ingredient is trapped within the hydrogel structure in its generated form. This merging of steps simplifies the overall process while maintaining the effectiveness established by the electrolytic generation method.

Inventive Principle:
Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The anhydrous SDC/citric acid composition effectively inhibits microbial growth in diverse settings, including medical, construction, and agricultural applications, offering a convenient and efficient antimicrobial solution without the need for reconstitution.

Implementation Method 1

an anhydrous composition of silver dihydrogen citrate (SDC) and citric acid is used directly in non-aqueous formulations, incorporated into various materials and surfaces without reconstitution, providing antimicrobial protection

Methodology Applied
Scientific EffectAntimicrobial action:

Data Source

PatentEP2464235B1Formulations and methods employing anhydrous disinfectant
Publication Date: 2017.07.12 PURE BIOSCIENCE INC

AI summary

Use of dried compositions of silver dihydrogen citrate along with citric acid in antimicrobial amounts directly as disinfectants is described.