Animal Feed Cannabinoid Dosage Based on Metabolizable Energy
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Solution Overview
Problem
Current animal feed rations containing cannabinoids lack controlled formulations to limit daily cannabinoid intake based on animal size and metabolizable energy requirements, potentially leading to adverse effects if excessive amounts are consumed.
Innovation Solution
Developing animal feed rations with specific concentrations of cannabidiol (CBD) and cannabidiolic acid (CBDA) within safe limits, calculated based on daily metabolizable energy requirements, to ensure safe and effective cannabinoid intake, with a CBDA:CBD ratio of at least 1:20, and incorporating these compounds into extruded or pelletized feeds to maintain bioactivity while preventing excessive exposure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cannabinoids are added to animal feed rations to provide beneficial effects, then health benefits are improved, but adverse effects occur when excessive amounts are consumed
Solution Approach 1:
The patent applies parameter changes by establishing specific concentration ranges for cannabinoids in animal feed based on animal body weight and metabolizable energy requirements. The formulation specifies that cannabinoid content should not exceed certain thresholds (e.g., 0.504 mg/kg body weight) to maintain beneficial effects while preventing adverse reactions. This quantitative parameter control resolves the contradiction by defining safe operational boundaries.
Solution Approach 2:
The patent implements feedback mechanisms through monitoring and testing protocols that measure cannabinoid concentrations in feed and animal responses. The formulation process includes determining daily metabolizable energy requirements and adjusting cannabinoid amounts accordingly, creating a closed-loop system that prevents excessive intake while maintaining therapeutic benefits.
2Reliability
If high concentrations of cannabinoids are used to achieve desired bioactivity, then therapeutic effects are improved, but safety limits are exceeded
Solution Approach 1:
The patent resolves this contradiction by changing the parameter of cannabinoid concentration to specific safe thresholds. The formulation specifies maximum concentrations based on animal species, body weight, and energy requirements, ensuring that bioactivity is achieved within safe limits. For example, it defines maximum cannabinoid content as a function of daily metabolizable energy requirements to prevent hepatoxicity while maintaining therapeutic effects.
Solution Approach 2:
The patent applies local quality by tailoring cannabinoid concentrations to specific animal categories and individual needs. Different feed formulations are created for different animal species, ages, and activity levels, with each formulation optimized for that specific group's requirements. This localized approach ensures optimal bioactivity for each animal while preventing excessive intake.
3Reliability
If cannabinoids are incorporated into feed to manage conditions like inflammation and pain, then therapeutic benefits are improved, but control over daily intake is lost
Solution Approach 1:
The patent applies universality by creating feed formulations that can be used across multiple animal species and conditions with a single standardized approach. The formulation process universally determines daily metabolizable energy requirements and calculates safe cannabinoid amounts based on body weight and energy needs, providing a universal template that simplifies intake control while maintaining therapeutic benefits across different applications.
Solution Approach 2:
The patent resolves the control issue by changing the parameter of daily intake calculation to be based on measurable animal characteristics (body weight, energy requirements). This transforms subjective dosing into objective, measurable parameters, making it easier to control and monitor daily cannabinoid intake while maintaining therapeutic effects.
4Reliability
If CBDA is maintained in its bioactive form through cold processing, then therapeutic efficacy is improved, but processing temperature control is required
Solution Approach 1:
The patent resolves this contradiction by changing the processing temperature parameter to remain below specific thresholds (e.g., below 80°C) to preserve CBDA in its bioactive form. The formulation specifies temperature ranges for processing, storage, and handling that maintain cannabinoid integrity while preventing degradation. This parameter control simplifies the complexity by providing clear temperature guidelines.
Data Source
AI summary
A method for using an animal feed ration to safely stimulate the endocannabinoid system of an animal includes determining a daily metabolizable energy requirement (DMER) for a class of animals. Further, the method includes providing an animal feed ration meeting the daily metabolizable energy requirement (DMER) to at least one animal in said class of animals based on the body weight (BW) the said animals measurable in kilograms (kg). The method further includes determining a daily metabolizable energy requirement (DMER) using a formula such as: DMER=RERMUL*β (kgBV)−α.