Animal Nutrition Composition Reducing MAP Kinase Activity

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Solution Overview

Problem

Current compositions for animal consumption do not effectively reduce mitogen-activated protein (MAP) kinase activity, which is associated with cancer and tissue hyperplasia, necessitating a need for compositions that can modulate MAP kinase activity to treat these conditions.

Innovation Solution

Compositions comprising at least 35% protein, less than 30% carbohydrates, and a specific ratio of omega-3 to omega-6 polyunsaturated fatty acids (0.3:1 to 5:1) are developed for animal consumption, including foods, supplements, and toys, to reduce MAP kinase activity and treat associated cancers and tissue hyperplasias.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional animal formulations are used, then basic nutritional requirements are met, but MAP kinase activity remains elevated and cancer/tissue hyperplasia treatment is ineffective

Engineering Contradiction:

Improveeffectiveness in reducing MAP kinase activityVSAvoidelevated MAP kinase activity associated with cancer and tissuehyperplasia

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies parameter changes by precisely controlling the omega-6 to omega-3 fatty acid ratio within the range of 0.3:1 to 5:1. This specific parameter adjustment transforms the composition from a conventional nutritional formulation into a therapeutic intervention that effectively reduces MAP kinase activity, thereby treating cancer and tissuehyperplasia while maintaining basic nutritional requirements

Inventive Principle:

Principle #35Parameter changes

2Reliability

If the composition focuses on reducing MAP kinase activity, then therapeutic benefit for cancer is achieved, but the formulation becomes more complex with specific fatty acid ratios

Engineering Contradiction:

Improvetherapeutic benefit for cancer treatmentVSAvoidformulation complexity due to specific fatty acid ratio requirements

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies universality by designing a composition that simultaneously provides basic nutritional functions (protein, carbohydrate, fat content within standard ranges) and therapeutic functions (reducing MAP kinase activity through controlled fatty acid ratios). This multi-functionality allows the same formulation to serve both as general animal food and as a cancer treatment intervention

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The patent manages formulation complexity by establishing clear parameter ranges (protein: ≥35%, carbohydrate: <30%, fat: specific ratio of omega-6 to omega-3 fatty acids). These defined parameters provide guidance for manufacturing while achieving the dual purpose of nutrition and therapy without excessive complexity

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS7744917B2Composition for animal consumption and method for reducing MAP kinase activity

Publication Date: 2010.06.29 VIRGINIA TECH INTELLECTUAL PROPERTIES INC

AI summary

This invention is directed generally to compositions (including foods nutritional supplements, treats, and toys) for animal consumption, particularly compositions that comprise omega-3 and omega-6 polyunsaturated fatty acids, and particularly compositions that tend to aid in reducing mitogen-activated-protein (“MAP”) kinase activity in animals. This invention also is directed generally to methods for using such compositions, particularly to methods for using such compositions to reduce MAP kinase activity in animals, and particularly to methods for using such compositions to treat a cancer or tissue hyperplasia. This invention is further directed generally to processes for making such compositions.