Anionic Cannabinoid Compositions for Water-Soluble Beverages
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Solution Overview
Problem
Cannabinoid molecules are insoluble in water, limiting the formulation of beverages and reducing their bioavailability.
Innovation Solution
Cannabinoid molecules are deprotonated to produce anionic cannabinoids, which are then dissolved in protic polar solvents like water or ethanol, forming stable solutions with delocalized negative charges on aromatic rings.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If cannabinoid molecules are used in their conventional form, then they maintain their natural chemical structure, but they exhibit poor solubility in water and limited bioavailability
Solution Approach 1:
The patent applies parameter changes by deprotonating the hydroxyl group of cannabinoid molecules to convert them into anionic forms. This chemical modification changes the electrical charge parameter of the molecule from neutral to negative, which dramatically improves water solubility while maintaining the core cannabinoid structure and biological activity. The anionic form allows the cannabinoid to interact favorably with polar water molecules through ion-dipole interactions.
2Quantity of substance
If cannabinoid molecules are deprotonated to form anionic cannabinoids, then solubility in water improves, but the chemical structure is modified
Solution Approach 1:
The patent applies preliminary action by performing deprotonation of the hydroxyl group before formulation and administration. This pre-modification step converts the cannabinoid into its anionic form, which is then stable in aqueous environments. The delocalization of the negative charge across the aromatic ring system stabilizes the anionic form, preventing spontaneous protonation or degradation during storage and use.
Solution Approach 2:
The patent converts the potentially harmful effect of poor solubility into a benefit by deliberately modifying the chemical structure to enhance water compatibility. The deprotonation, which initially appears to alter the natural structure, actually resolves the solubility problem while maintaining biological activity, turning a formulation challenge into an advantage.
3Reliability
If conventional cannabinoid formulations are used, then the natural form is preserved, but bioavailability is limited due to poor water solubility
Solution Approach 1:
The patent changes the electrical charge parameter of the cannabinoid molecule by deprotonating the hydroxyl group, creating an anionic form that is highly soluble in water. This parameter change directly addresses the bioavailability issue by enabling the cannabinoid to dissolve in the aqueous environments of the body (gastrointestinal fluids, blood plasma), thereby improving absorption and delivery to target sites.
Data Source
AI summary
This patent document discloses compositions, containers, and methods related to anionic cannabinoids that contain oxide substituents. The anionic cannabinoids may be prepared from cannabinoid molecules, for example, by contacting the cannabinoid molecules with a strong base. The anionic cannabinoids generally display improved solubility in water.