Composite Particles Formed by Anionic Polymer and Cationic Peptide
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Solution Overview
Problem
Hyaluronan and chitosan easily form composite particles, but it is unknown which polymers with what properties can form such particles under specific conditions, and anionic polymers and peptides struggle to form composite particles with small diameters under neutral conditions.
Innovation Solution
The formation of composite particles with anionic polymers like hyaluronan and polyglutamic acid, and cationic polymers such as allyl-based amines or peptides, where the cationic polymer has a degree of cationization of 0.2 or more, and mixing these in an aqueous solvent at neutral or acidic pH to prevent aggregation and achieve small particle diameters.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If anionic polymer and peptide are mixed under neutral conditions, then the mixture is stable, but composite particles with small diameters cannot be formed
Solution Approach 1:
The patent changes the pH parameter from neutral to acidic conditions to enable the formation of composite particles with small diameters. This parameter change allows the anionic polymer and peptide to form stable composite particles while achieving the desired small size, resolving the contradiction between stability and particle diameter.
2Device complexity
If conventional carriers are used to deliver active components, then the formulation is simple, but skin permeability is insufficient
Solution Approach 1:
The patent uses composite particles formed by combining anionic polymer and peptide materials. This composite structure enables effective skin permeation while maintaining relative formulation simplicity, resolving the contradiction between formulation complexity and skin permeability.
3Reliability
If polymer compounds are used as active components, then the therapeutic effect is significant, but permeation through horny layer is difficult
Solution Approach 1:
The patent embeds the polymer active component within the composite particle structure formed by anionic polymer and peptide. This nesting approach allows the polymer to be delivered through the skin barrier while maintaining its therapeutic function, resolving the contradiction between therapeutic effect and permeation capability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method allows for the production of stable composite particles that can permeate the skin, delivering anionic polymers and peptides effectively, improving skin permeability and barrier function.
Implementation Method 1
composite particles including an anionic polymer and cationic polymer or peptide
Data Source
AI summary
A first problem is to provide a novel technique for forming hyaluronan into particles. Further, a second problem is to provide a novel technique suitable for production of a composite particle containing an anionic polymer and a peptide.Means for solving the first problem is a composite particle containing an anionic polymer, and a cationic polymer (except for chitosan) having a degree of cationization of 0.2 or more. Means for solving the second problem is to mix an anionic polymer and a peptide in an aqueous solvent having a pH of 5 or less.