Anionic Polymer Anti-Platelet Composition for Surgical Adhesion Prevention

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Solution Overview

Problem

Surgical adhesions, which occur in a significant percentage of surgeries, lead to complications such as pain, functional deficits, and increased healthcare costs due to the formation of scar tissue that restricts organ mobility and function, and current methods are inadequate in preventing these adhesions effectively.

Innovation Solution

Compositions comprising anionic polymers or monomers, such as dextran sulfate, combined with anti-platelet agents like Tirofiban, are used to inhibit platelet activation and aggregation, thereby preventing fibrosis and surgical adhesions by regulating the wound-healing process and inhibiting fibroblast invasion.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional surgical methods are used, then surgical procedures can be performed, but postoperative adhesions occur in 67-93% of patients causing pain and functional deficits

Engineering Contradiction:

Improveadhesion prevention effectivenessVSAvoidsurgical adhesion formation

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The anionic polymer composition is applied to the surgical site before adhesions can form, preventing platelet activation and fibroblast invasion in advance. The composition is applied immediately during surgery to the tissue surfaces that will be in contact, creating a protective barrier before the pathological adhesion formation process begins

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The anionic polymer composition acts as an intermediary substance between tissue surfaces that would otherwise adhere to each other. It forms a physical and chemical barrier that prevents direct contact between opposing tissue surfaces, thereby preventing the formation of adhesions while still allowing the surgical procedure to proceed

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If scar tissue formation is allowed for normal wound healing, then proper wound healing occurs, but scar tissue overgrows and creates adhesions

Engineering Contradiction:

Improvewound healing qualityVSAvoidexcessive scar tissue

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The anionic polymer composition modifies the biochemical parameters of the wound healing environment by inhibiting platelet activation and fibroblast proliferation. This changes the balance of the healing process, allowing necessary wound closure while preventing excessive scar tissue formation that leads to adhesions

Inventive Principle:

Principle #35Parameter changes

3Ease of manufacture

If no adhesion prevention is used, then surgical procedures are simpler, but adhesions cause pain, functional deficit, and increased healthcare costs

Engineering Contradiction:

Improvesurgical procedure simplicityVSAvoidadhesion-related complications

Core Design Contradiction:

Ease of manufactureVSObject-affected harmful factors

Solution Approach 1:

The anionic polymer composition is applied locally to specific tissue surfaces at the surgical site where adhesion prevention is needed. This localized application provides targeted protection without requiring complex systemic treatments, maintaining surgical simplicity while addressing the specific problem area

Inventive Principle:

Principle #3Local quality

Data Source

PatentUS8680075B2Methods and compositions for inhibiting cellular proliferation and surgical adhesion

Publication Date: 2014.03.25 NOVELMED THERAPEUTICS INC

AI summary

A method for inhibiting cellular proliferation of fibroblasts and/or glioma cells in a mammal includes administering a composition to a mammal wherein the composition includes an amount of an anionic polymer and an anti-platelet agent effective to inhibit cellular proliferation of fibroblasts and gliomas in the mammal.