Anise and Onion Oil Composition for Hypoglycemic Treatment
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Solution Overview
Problem
Current hypoglycemic treatments for diabetes, such as insulin injections and oral hypoglycemic agents, often lead to drug resistance and significant side effects, making them less effective over time and posing health risks.
Innovation Solution
A hypoglycemic composition comprising 1-99 parts by weight of anise oil and 1-99 parts by weight of onion oil, obtained through steam distillation, which inhibits aldose reductase and α-glucosidase, and includes active ingredients like sulfonylurea butyric acid and sulfur compounds to prevent insulin oxidation, offering a synergistic hypoglycemic effect with minimal side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional hypoglycemic agents (biguanides and sulfonylureas) are used for long-term treatment, then initial hypoglycemic effect is achieved, but drug resistance develops and side effects increase
Solution Approach 1:
The patent extracts and utilizes specific active components from natural sources (onion sulfur compounds and anise compounds) to create a hypoglycemic formulation that achieves therapeutic effects without the harmful side effects associated with conventional synthetic hypoglycemic agents
Solution Approach 2:
The patent converts naturally occurring compounds from common foods (onion and anise) into a therapeutic agent that provides hypoglycemic effects. These natural compounds work synergistically to improve insulin sensitivity and reduce blood glucose without causing the drug resistance and severe side effects of conventional medications
2Reliability
If traditional Chinese medicine formulations are used, then potential hypoglycemic effects are achieved, but quality control becomes difficult
Solution Approach 1:
The patent specifies precise parameters for the composition including the use of specific compounds (onion sulfur compounds, anise compounds) with defined functional characteristics, enabling consistent quality control while maintaining traditional Chinese medicine principles
Solution Approach 2:
The patent creates a composite formulation combining specific onion extracts and anise extracts in defined proportions, where the synergistic interaction between components provides reliable hypoglycemic effects while the standardized composition ensures consistent quality
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces blood glucose levels and improves glucose tolerance with no significant side effects, as demonstrated in rat models, providing a safer alternative for managing hyperglycemia.
Implementation Method 1
the anise oil in the hypoglycemic composition of the present invention can inhibit aldose reductase and α-glucosidase
Implementation Method 2
which prevent insulin from being destroyed by oxidation-reduction equilibrium
Implementation Method 3
the anise oil is obtained by subjecting anise to steam distillation; the onion oil is obtained by subjecting onion to steam distillation
Data Source
AI summary
The present invention provides a hypoglycemic composition and preparation method thereof, wherein the hypoglycemic composition comprises 1-99 parts by weight of anise oil and 1-99 parts by weight of onion oil. Compared with the prior art, the anise oil in the hypoglycemic composition of the present invention can inhibit aldose reductase and α-glucosidase. The active ingredients of onion oil are sulfonylurea butyric acid and volatile substances containing sulfur including alliin, allylpropyl disulfide, S-allylcysteine sulfoxide (SACS) and so on, which prevent insulin from being destroyed by oxidation-reduction equilibrium. Anise oil and onion oil act synergistically to facilitate the hypoglycemic effect; moreover, anise oil and onion oil can be both used as medicine and food, and have no side effect.