Anthocyanin-Polysaccharide Complex for Gastritis Treatment

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Solution Overview

Problem

Current treatments for gastritis and peptic ulcers have high recurrence rates and can cause side effects, such as gastric tumors and neuroendocrine cell tumors, necessitating a safer therapeutic agent.

Innovation Solution

A pharmaceutical composition comprising an anthocyanin-negatively charged polysaccharide complex, which forms a stable ionic bond with anthocyanin, enhancing its stability and absorption, is developed for the prevention and treatment of gastritis and peptic ulcers.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional drugs (antacids, anticholinergics, histamine antagonists) are used for treating gastritis and peptic ulcer, then the disease can be cured, but the recurrence rate is high and long-term use is required

Engineering Contradiction:

Improvecure rateVSAvoidtreatment duration

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent combines anthocyanin with negatively charged polysaccharides (such as alginic acid, carrageenan, or pectin) to form a composite complex. This composite structure provides both the ulcer-healing properties of anthocyanin and the protective mucosal effects of polysaccharides, enabling effective treatment with shorter duration and reduced recurrence compared to conventional single-agent therapies.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent modifies the chemical parameters of anthocyanin by forming ionic complexes with polysaccharides, which enhances the stability and bioavailability of anthocyanin. This parameter change allows the active ingredient to maintain effectiveness at lower concentrations and for shorter treatment periods, addressing the long-duration treatment issue.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If conventional drugs (ranitidine, cimetidine, famotidine, omeprazole) are used for long-term treatment of gastric ulcer, then the disease can be controlled, but side effects such as gastric tumors and neuroendocrine cell tumors occur

Engineering Contradiction:

Improvedisease controlVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The patent employs natural, biodegradable polysaccharides (alginic acid, carrageenan, pectin) as carriers for anthocyanin. These natural polymers are safely metabolized by the body and do not accumulate, eliminating the tumorigenic side effects associated with long-term use of synthetic conventional drugs while maintaining effective disease control.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The negatively charged polysaccharides act as intermediary carriers that deliver anthocyanin to the gastric mucosa. This intermediary system protects the active ingredient from degradation, enhances its targeted delivery to ulcer sites, and reduces systemic exposure that causes side effects, thereby maintaining disease control with improved safety.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Reliability

If anthocyanin is used alone for treating gastritis and peptic ulcer, then some therapeutic effect is achieved, but the stability and absorption are insufficient

Engineering Contradiction:

Improvetherapeutic effectVSAvoidstability and absorption

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent creates a composite complex where anthocyanin is bound to negatively charged polysaccharides through ionic interactions. This composite structure protects anthocyanin from oxidation and degradation in the gastrointestinal tract, significantly enhancing its stability and oral bioavailability while maintaining or improving its therapeutic effect on gastritis and peptic ulcers.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The anthocyanin-negatively charged polysaccharide complex exhibits a synergistic effect, providing improved preventive and therapeutic benefits for gastritis and peptic ulcers with enhanced stability and absorption, reducing recurrence rates and side effects.

Implementation Method 1

anthocyanin-negatively charged polysaccharide complex, which forms a stable ionic bond with anthocyanin

Methodology Applied

Scientific EffectIonic bond: Chemical Bonding

Data Source

PatentUS20220249675A1Composition for Preventing, Ameliorating, or Treating Gastritis or peptic Ulcer Comprising Anthocyanin-Negatively Charged Polysaccharide Complex as Active Ingredient

Publication Date: 2022.08.11 JBKLAB CO LTD

AI summary

The present invention relates to a composition for preventing, ameliorating, or treating gastritis or peptic ulcer, comprising an anthocyanin-negatively charged polysaccharide complex as an active ingredient and, more specifically, to a composition for preventing, ameliorating, or treating gastritis or peptic ulcer, comprising an anthocyanin-negatively charged polysaccharide complex as an active ingredient, the composition exhibiting a synergistic effect as compared to anthocyanins or each of negatively charged polysaccharides. The composition comprising an anthocyanin-negatively charged polysaccharide complex as an active ingredient provided by the present invention exhibits a significantly excellent effect of relieving lesions of gastritis or peptic ulcer, and thus can be very effectively used in the development of a composition for preventing, ameliorating, or treating gastritis or peptic ulcer.