Anthranilamide Insecticidal Mixtures Synergy

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Solution Overview

Problem

Current insecticidal combinations often fail to achieve synergistic effects, leading to reduced activity and increased resistance in pest control, necessitating the development of compositions that combine anthranilamide compounds with other insecticidal agents to enhance spectrum and duration of control while managing resistance.

Innovation Solution

An insecticidal mixture comprising an anthranilamide compound of formula (I) combined with at least one insecticidal compound, applied simultaneously or separately, to achieve synergistic control of insect pests, reducing dosage rates and promoting prolonged activity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If conventional insecticidal combinations are used, then the spectrum of control is broadened, but synergistic effects are rarely attained and activity is reduced

Engineering Contradiction:

Improvespectrum of controlVSAvoidinsecticidal activity

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The patent changes the chemical parameter by selecting specific anthranilamide compounds with particular molecular structures and substitution patterns (R1-R6 groups) to achieve enhanced insecticidal activity. This parameter change in chemical structure enables synergistic effects when combined with other insecticides, resolving the contradiction between broad spectrum and maintained activity.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent creates composite insecticidal compositions by combining anthranilamide compounds with other insecticidal agents having different modes of action. This composite approach achieves both broadened spectrum of control and synergistic enhancement of activity, simultaneously addressing both requirements.

Inventive Principle:

Principle #40Composite materials

2Quantity of substance

If repeated application of individual active compounds is used, then cost of treatment is reduced, but resistance development occurs

Engineering Contradiction:

Improvecost of treatmentVSAvoideffectiveness against resistant pests

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The patent merges multiple insecticidal compounds with different modes of action into a single composition. This combination approach prevents resistance development because pests cannot easily develop resistance to multiple different mechanisms simultaneously, while the additive or synergistic effects reduce the quantity of each individual substance needed, maintaining cost-effectiveness.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The patent changes the chemical parameter by selecting insecticides with different modes of action (MOA) for combination, specifically incorporating anthranilamides that act on ryanodine receptors. This parameter change in mechanism of action prevents resistance cross-over and maintains long-term effectiveness.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If mixtures of different active compounds are used, then resistance management is improved, but the activity and selectivity behavior becomes difficult to predict

Engineering Contradiction:

Improveresistance managementVSAvoidpredictability of mixture behavior

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent changes the chemical parameter by selecting insecticides with well-defined and different modes of action, particularly anthranilamides acting on ryanodine receptors combined with other classes. This systematic selection based on MOA parameters makes the mixture behavior more predictable while maintaining effective resistance management.

Inventive Principle:

Principle #35Parameter changes

4Reliability

If higher doses of insecticides are applied, then control effectiveness is improved, but chemical usage and environmental impact increase

Engineering Contradiction:

Improvecontrol effectivenessVSAvoidchemical usage

Core Design Contradiction:

ReliabilityVSLoss of substance

Solution Approach 1:

The patent converts the potential harm of insecticide resistance and reduced efficacy into a benefit by using combinations that produce synergistic effects. This synergy allows achieving better control effectiveness at lower doses, reducing chemical usage and environmental impact while maintaining or improving efficacy.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The patent creates composite compositions combining anthranilamide compounds with other insecticides to achieve synergistic effects. This composite approach enhances control effectiveness per unit of chemical applied, reducing the total quantity needed while improving reliability of pest control.

Inventive Principle:

Principle #40Composite materials

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The combination exhibits enhanced insecticidal activity, broadened spectrum, and improved resistance management, providing effective control with reduced chemical usage and cost.

Implementation Method 1

These compounds activate this receptor, leading to the unregulated loss of stored calcium. This causes impaired regulation of muscle contraction.

Methodology Applied

Scientific EffectRyanodine receptor activation:

Data Source

PatentUS20230053477A1Insecticidal Mixtures

Publication Date: 2023.02.23 ADAMA MAKHTESHIM LTD

AI summary

The present invention relates to insecticidal mixtures comprising a) an anthranilamide compound of formula (I) and b) an insecticidal compound.