Synergistic Anthranilic Acid Amide Mixtures for Itching Relief
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Solution Overview
Problem
Existing cosmetic and pharmaceutical compositions containing anthranilic acid amides for alleviating itching often require high concentrations, which can be problematic for formulation technology, and there is a need for synergistic combinations that can achieve effective itching relief with lower concentrations.
Innovation Solution
A mixture comprising dihydroavenanthramide D and climbazole, which interacts synergistically with anthranilic acid amides to provide effective itching relief and skin reddening reduction, even at low use concentrations, by combining with other active compounds such as antidandruff agents, skin moisture regulators, cooling agents, and osmolytes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high concentrations of anthranilic acid amides are used to achieve effective itching relief, then the therapeutic effect is improved, but formulation technology becomes problematic and the complexity of the composition increases
Solution Approach 1:
The patent combines dihydroavenanthramide D (an anthranilic acid amide) with climbazole (an antidandruff agent) in a synergistic mixture. This merging of two different active compounds allows each to enhance the other's effectiveness, enabling lower individual concentrations while maintaining or improving overall itching relief efficacy and reducing formulation complexity.
2Reliability
If high concentrations of anthranilic acid amides are used to ensure therapeutic effectiveness, then the itching relief is improved, but the quantity of substance required increases
Solution Approach 1:
By merging dihydroavenanthramide D with climbazole in a synergistic combination, the patent achieves enhanced itching relief at lower concentrations of each individual compound. The synergistic interaction means the combined effect exceeds the sum of individual effects, reducing the total quantity of substance needed while improving therapeutic effectiveness.
Solution Approach 2:
The patent creates a composite active compound system consisting of dihydroavenanthramide D and climbazole working together. This composite approach allows the mixture to achieve superior anti-itch activity at lower concentrations compared to using either compound alone, effectively reducing the quantity of substance required for therapeutic effect.
Data Source
AI summary
The invention relates to a mixture comprising or consisting of: (a) one or more compounds of Formula 1 : where the symbols in the compound or each compound of Formula 1 are defined as follows: m = 0, 1 , 2 or 3, P = O, 1 or 2, n = 0, 1 or 2, where, when n = 1 or 2, R1 and R2 in pairs are each H or together are another chemical bond, where, when m = 1 , 2 or 3, each X independently of the others is OH, Oalkyl or Oacyl, and where, when p = 1 or 2, each Y independently of the others is OH, Oalkyl or Oacyl, and R3 = H or alkyl, R3 = H also representing the corresponding cosmetically or pharmaceutically acceptable salts and solvates; and (b) one or more antidandruff agents.