Anti-adhesion Material With Aliphatic Ester Cover Layer
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Solution Overview
Problem
Conventional anti-adhesion materials, particularly those using water-soluble polymers like hyaluronic acid, are inferior in handling properties under wet conditions and do not meet the required levels of in vivo degradability and anti-adhesion characteristics.
Innovation Solution
An anti-adhesion material with a base layer containing a water-soluble polymer and a cover layer made of aliphatic ester, where the optical thickness of the cover layer is set between 27 nm and 160 nm, improving handling properties while maintaining sufficient in vivo degradability and anti-adhesion characteristics.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a water soluble polymer such as hyaluronic acid is used as the anti-adhesion material, then biocompatibility and in vivo degradability are excellent, but handling properties under wet conditions are extremely inferior
Solution Approach 1:
The anti-adhesion material is divided into two functional layers: a base layer containing water-soluble polymer for biocompatibility and degradability, and a cover layer containing hydrophobic polymer for improved wet handling properties. This segmentation allows each layer to fulfill its specific function without compromising the other.
Solution Approach 2:
The invention uses a composite structure combining water-soluble polymer (base layer) with hydrophobic polymer (cover layer). The base layer provides biocompatibility and degradability while the cover layer provides water resistance and improved handling properties under wet conditions.
2Ease of operation
If a support layer is added to improve handling properties under wet conditions, then handling properties are expected to improve, but in vivo degradability and anti-adhesion characteristics fail to reach required levels
Solution Approach 1:
The cover layer is designed with specific thickness control (optical thickness 27-160 nm) to provide local hydrophobic protection at the surface while allowing the underlying base layer to maintain its water-soluble characteristics for degradability and anti-adhesion function. The localized modification preserves bulk properties while improving surface performance.
Data Source
Figure 1(a)~2(b)
Figure 3(a)~4(b)
Figure 5
AI summary
An object of the present invention is to provide an anti-adhesion material having sufficient in vivo degradability and excellent anti-adhesion characteristics, and also superior to conventional ones in terms of handling properties under wet conditions. The anti-adhesion material (1) of the present invention has a sheet-like base layer (10) containing a water soluble polymer (e.g., pullulan), a first cover layer (20) placed on a surface on one side of the base layer (10) and containing an aliphatic ester, and a second cover layer (30) placed on a surface on the other side of the base layer (10) and containing an aliphatic ester. The optical thickness of each of the first cover layer (20) and the second cover layer (30) is set to be 27 nm or greater and smaller than 160 nm.