Anti-aging Composition Plant Extracts Longevity Pathways
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Solution Overview
Problem
Current treatments do not effectively delay aging of the entire organism by targeting multiple cellular and organismal processes using natural extracts, and there is a need for interventions that mimic the aging-delaying effects of dietary restriction or lifespan-extending genetic mutations.
Innovation Solution
An anti-aging composition comprising at least two different plant extracts, such as Black cohosh, Valerian, Ginkgo biloba, Celery seed, or Passion flower extracts, combined with agents like resveratrol, metformin, or spermidine, which modulate pathways like TORC1, cAMP/PKA, PKH1/2, SNF1/AMPK, and ATG to regulate longevity and delay age-related disorders.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If dietary restriction is implemented to delay aging, then lifespan extension is achieved, but food consumption must be limited to the equivalent of a 5 year old child which is difficult to implement in adults
Solution Approach 1:
The patent introduces plant extracts (such as resveratrol from grapes, curcumin from turmeric, and other natural compounds) as intermediary substances that mediate the anti-aging effects typically achieved through dietary restriction. These extracts act as bioactive molecules that can be consumed in manageable amounts while still activating longevity pathways, thus providing the lifespan benefits without requiring extreme caloric limitation.
Solution Approach 2:
The patent modifies the approach by changing the chemical parameters of the intervention from simple caloric restriction to specific bioactive compound administration. By identifying and administering specific plant-derived compounds with anti-aging properties, the patent achieves the desired physiological effects through molecular parameter changes rather than through drastic changes in consumption quantity.
2Duration of action of moving object
If rapamycin is used to inhibit mTOR and extend lifespan, then significant lifespan extension is achieved, but many negative side effects occur
Solution Approach 1:
The patent replaces the potent but harmful synthetic drug rapamycin with natural plant extracts that have milder, more tolerable profiles. These natural compounds (such as curcumin, resveratrol, and other phytochemicals) serve as alternative longevity agents that achieve partial mTOR inhibition and other anti-aging effects without the severe side effects associated with rapamycin, effectively substituting a harmful short-term solution with a safer long-term alternative.
Solution Approach 2:
The patent identifies harmful side effects of conventional anti-aging drugs and converts the search for alternatives into a benefit by discovering and validating the safety and efficacy of natural plant extracts. The natural compounds provide the desired anti-aging effects while inherently avoiding the harmful effects of synthetic drugs, thus transforming the problem of drug toxicity into an opportunity to find safer, nature-based solutions.
3Reliability
If complex mixtures of several natural products are used to modulate different signaling pathways, then more important anti-aging effect is achieved, but the complexity of the composition increases
Solution Approach 1:
The patent segments the anti-aging approach by identifying and isolating specific individual plant extracts or key compounds within plant mixtures that have the most potent anti-aging effects. Rather than requiring complex multi-component formulations, the patent demonstrates that specific segmented components (such as curcumin from turmeric, resveratrol from grapes, or epigallocatechin gallate from green tea) can achieve significant anti-aging effects on their own or in simplified combinations, thus reducing formulation complexity while maintaining efficacy.
Data Source
AI summary
The present description relates to an anti-aging composition comprising at least one plant extract. The composition can comprise at least two different anti-aging agents, wherein one the anti-aging agent is a plant extract. The combination of two anti-aging agents has a superior effect on regulating longevity compared to the use of one anti-aging agent. The plant extract is preferably selected from the group consisting of a Black cohosh extract, a Valerian extract, a Ginkgo biloba extract, a Celery seed extract, a White willow extract and a Passion flower extract.